Repetitive DNA sequences are abundant in a broad range of species, from bacteria to
mammals, and they cover nearly half of the human genome. Repeats have always …

High-throughput RNA sequencing (RNA-seq) promises a comprehensive picture of the
transcriptome, allowing for the complete annotation and quantification of all genes and their …

Read alignment is an ongoing challenge for the analysis of data from sequencing
technologies. This article proposes an elegantly simple multi-seed strategy, called seed-and …

The use of big data research methods has grown tremendously over the past five years in
both academia and industry. As the size and complexity of available datasets has grown, so …

Despite gains in survival, outcomes for patients with metastatic or recurrent
rhabdomyosarcoma remain dismal. In a collaboration between the National Cancer Institute …

Polyploidy is observed across the tree of life, yet its influence on evolution remains
incompletely understood,,,. Polyploidy, usually whole-genome duplication, is proposed to …

Cancers are caused by the accumulation of genomic alterations. Therefore, analyses of
cancer genome sequences and structures provide insights for understanding cancer …

The accurate mapping of reads that span splice junctions is a critical component of all
analytic techniques that work with RNA-seq data. We introduce a second generation splice …

The evolutionarily conserved target of rapamycin (TOR) kinase acts as a master regulator
that coordinates cell proliferation and growth by integrating nutrient, energy, hormone and …

High-throughput sequencing technologies have strongly impacted microbiology, providing a
rapid and cost-effective way of generating draft genomes and exploring microbial diversity …