In recent years gene regulatory networks (GRNs) have attracted a lot of interest and many
methods have been introduced for their statistical inference from gene expression data …

The promise of 'personalized cancer care'with therapies toward specific molecular
aberrations has potential to improve outcomes. However, there is recognized heterogeneity …

With the advent of post-genomic era, new technologies create extraordinary possibilities for
diagnostics and personalized therapy, transforming todays' medicine. Rooted in both …

At the heart of the cellular machinery through the regulation of cellular functions, protein–
protein interactions (PPIs) have a significant role. PPIs can be analyzed with network …

Motivation Differential network analysis, designed to highlight network changes between
conditions, is an important paradigm in network biology. However, differential network …

Cartilage destruction in rheumatoid arthritis (RA) occurs primarily in the pannus-cartilage
interface. The close contact of the synovium-cartilage interface implicates crosstalk between …

Molecular research in cancer is one of the largest areas of bioinformatic investigation, but it
remains a challenge to understand biomolecular mechanisms in cancer-related pathways …

Poor prognosis for late‐stage, high‐grade, and recurrent cancers has been motivating
cancer researchers to search for more efficient biomarkers to identify the onset of cancer …

Background: Evaluation of gene interaction models in cancer genomics is challenging, as
the true distribution is uncertain. Previous analyses have benchmarked models using …

Developing improved approaches for diagnosis, treatment, and prevention of diseases is a
major goal of biomedical research. Therefore, the discovery of biomarker signatures from …