Molecular mechanisms of environmental exposures and human disease
A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …
environmental exposures and pollutants. An appreciation of how environmental pollutants …
Epigenetics of type 2 diabetes mellitus and weight change—a tool for precision medicine?
Pioneering studies performed over the past few decades demonstrate links between
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …
Physical activity is associated with slower epigenetic ageing—Findings from the Rhineland study
Epigenetic ageing, ie, age‐associated changes in DNA methylation patterns, is a sensitive
marker of biological ageing, a major determinant of morbidity and functional decline. We …
marker of biological ageing, a major determinant of morbidity and functional decline. We …
DNA methylation age acceleration is associated with risk of diabetes complications
VM Vetter, J Spieker, Y Sommerer… - Communications …, 2023 - nature.com
Abstract Background Patients with Type 2 diabetes mellitus (T2D) are at risk for micro-and
macrovascular complications. Implementable risk scores are needed to improve targeted …
macrovascular complications. Implementable risk scores are needed to improve targeted …
Associations of urban blue and green spaces with coronary artery calcification in black individuals and disadvantaged neighborhoods
BACKGROUND: Proximity to urban blue and green spaces has been associated with
improved cardiovascular health; however, few studies have examined the role of race and …
improved cardiovascular health; however, few studies have examined the role of race and …
Relative contributions of six lifestyle-and health-related exposures to epigenetic aging: the Coronary Artery Risk Development in Young Adults (CARDIA) Study
Background DNA methylation-based GrimAge acceleration (GrimAA) is associated with a
wide range of age-related health outcomes including cardiovascular disease. Since DNA …
wide range of age-related health outcomes including cardiovascular disease. Since DNA …
Gestational diabetes mellitus, epigenetic age and offspring metabolism
C Kim, KK Harrall, DH Glueck, BL Needham… - Diabetic …, 2022 - Wiley Online Library
Aims No reports examine the relationship between in‐utero exposure to gestational
diabetes mellitus (GDM), offspring epigenetic age acceleration (EAA), and offspring insulin …
diabetes mellitus (GDM), offspring epigenetic age acceleration (EAA), and offspring insulin …
The prospect of genomic, transcriptomic, epigenetic and metabolomic biomarkers for the personalized prevention of type 2 diabetes and cardiovascular diseases
A Zeljkovic, M Mihajlovic, S Vujcic… - Current Vascular …, 2023 - ingentaconnect.com
Cardiometabolic diseases, such as type 2 diabetes mellitus (DM) and cardiovascular
disease (CVD), are a great health concern. The strategies aimed to increase awareness and …
disease (CVD), are a great health concern. The strategies aimed to increase awareness and …
Investigating causality in the association between DNA methylation and type 2 diabetes using bidirectional two-sample Mendelian randomisation
DL Juvinao-Quintero, GC Sharp, ECM Sanderson… - Diabetologia, 2023 - Springer
Aims/hypothesis Several studies have identified associations between type 2 diabetes and
DNA methylation (DNAm). However, the causal role of these associations remains unclear …
DNA methylation (DNAm). However, the causal role of these associations remains unclear …
Role of epigenetics and metabolomics in predicting endothelial dysfunction in type 2 diabetes
N Di Pietrantonio, I Cappellacci, D Mandatori… - Advanced …, 2023 - Wiley Online Library
Abstract Type 2 diabetes (T2D) is a worldwide health problem and cardiovascular disease
(CVD) is a leading cause of morbidity and mortality in T2D patients, making the prevention of …
(CVD) is a leading cause of morbidity and mortality in T2D patients, making the prevention of …