Small molecule metabolites: discovery of biomarkers and therapeutic targets

S Qiu, Y Cai, H Yao, C Lin, Y Xie, S Tang… - Signal Transduction and …, 2023 - nature.com
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Remodelling of the intestinal ecosystem during caloric restriction and fasting

QR Ducarmon, F Grundler, Y Le Maho… - Trends in …, 2023 - cell.com
Benefits of fasting and caloric restriction on host metabolic health are well established, but
less is known about the effects on the gut microbiome and how this impacts renewal of the …

Gut microbiome diversity and composition in individuals with and without extended-spectrum β-lactamase-producing Enterobacterales carriage: a matched case …

A Boyd, M El Dani, R Ajrouche, V Demontant… - Clinical Microbiology …, 2024 - Elsevier
Objective Little is known about the effect of gut microbial and extended-spectrum β-
lactamase-producing Enterobacterales (ESBL-E) carriage, particularly in the general …

Gut microbiome dynamics in index patients colonized with extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales after hospital discharge and their …

J Top, TD Verschuuren, MC Viveen… - Microbiology …, 2023 - Am Soc Microbiol
This study investigated the gut microbiome dynamics of index patients colonized with
extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-Ec)(n= 5) or extended …

Gut colonization by ESBL-producing Escherichia coli in dogs is associated with a distinct microbiome and resistome composition

PB Stege, J Hordijk, AKS Sandholt, AL Zomer… - Microbiology …, 2023 - Am Soc Microbiol
The gut microbiome of humans and animals acts as a reservoir of extended-spectrum beta-
lactamase-producing Escherichia coli (ESBL-EC). Dogs are known for having a high …

Profiling the fecal microbiome and its modulators across the lifespan in the Netherlands

D Boverhoff, J Kool, R Pijnacker, QR Ducarmon… - Cell reports, 2024 - cell.com
Defining what constitutes a healthy microbiome throughout our lives remains an ongoing
challenge. Understanding to what extent host and environmental factors can influence it has …

Risk factors for diarrheagenic Escherichia coli infection in children aged 6–24 months in peri-urban community, Nairobi, Kenya

NO Okumu, JJN Ngeranwa, DM Muloi… - PLOS global public …, 2023 - journals.plos.org
Escherichia coli commonly inhabits the gut of humans and animals as part of their
microbiota. Though mostly innocuous, some strains have virulence markers that make them …

Influence of ESBL colonization status on gut microbiota composition during allogenic hematopoietic stem cell transplantation

S Corcione, I Ferrocino, T Lupia, A Busca, G Bianco… - Scientific Reports, 2025 - nature.com
After allogeneic HSCT (allo-HSCT), the diversity of the intestinal microbiota significantly
decreases. The changes can be rapid and are thought to be caused by chemotherapy …

A new complex of silver (I) with probenecid: Synthesis, characterization, and studies of antibacterial and extended spectrum β-lactamases (ESBL) inhibition activities

WR Lustri, SC Lazarini, NAS Aquaroni… - Journal of Inorganic …, 2023 - Elsevier
This article describes the in vitro antibacterial and β-lactamase inhibition of a novel silver (I)
complex with the sulfonamide probenecid (Ag-PROB). The formula Ag 2 C 26 H 36 N2O 8 S …

Recovery of the gut microbiome following enteric infection and persistence of antimicrobial resistance genes in specific microbial hosts

ZA Hansen, K Vasco, JT Rudrik, KT Scribner… - Scientific Reports, 2023 - nature.com
Enteric pathogens cause widespread foodborne illness and are increasingly resistant to
important antibiotics yet their ecological impact on the gut microbiome and resistome is not …