Small noncoding RNAs play an important role in various disease states, including cancer.
PIWI proteins, a subfamily of Argonaute proteins, and PIWI-interacting RNAs (piRNAs) were …

The blood-tumor barrier (BTB) restricts the efficient delivery of anti-glioma drugs to cranial
glioma tissues. Increased BTB permeability may allow greater delivery of the therapeutic …

Background Colorectal cancer (CRC) is one the leading causes of cancer related deaths
among Iranians. Despite the various progresses in new therapeutic methods, it has still a …

The PIWI‐like protein 1 (PIWIL1) plays a crucial role in stem cell proliferation,
embryogenesis, growth, and development, as well as differentiation and maturation in …

PIWI proteins, traditionally associated with germline development, have recently gained
attention for their expression in various cancers, including colorectal cancer. However, the …

Introduction: Colorectal cancer (CRC) is one of the most important common causes of
cancer-related death globally and reorganization of regulatory mechanisms controlling …

Background/Aim: Cancer stem cells (CSCs) constitute a sub-population of tumor cells that
possess stem cell properties, such as self-renewal and the ability of differentiation. The …

Gastric cancer (GC) as the fourth most common cause of malignancies shows high rate of
morbidity appropriating the second leading cause of cancer-related death worldwide …

Hiwi is well known for its role in stem cell renewal, maintaining the resting stage, and
downregulating cell cycle of stem cells via RNA silencing. And Hiwi overexpression has …

Background: Colorectal cancer is a heterogeneous disease that leads to metabolic
disorders due to multiple upstream genetic and molecular changes and interactions. The …