Genetics insight for COVID-19 susceptibility and severity: a review
I Fricke-Galindo, R Falfán-Valencia - Frontiers in immunology, 2021 - frontiersin.org
Coronavirus disease (COVID-19) presents a broad spectrum of clinical manifestations
ranging from an asymptomatic to a severe clinical course. The host genetic background …
ranging from an asymptomatic to a severe clinical course. The host genetic background …
The known unknowns of T cell immunity to COVID-19
Tremendous progress has been made in understanding the role of T cell immunity in acute
and convalescent COVID-19 infection. Here, we shed light on the “known unknowns” of …
and convalescent COVID-19 infection. Here, we shed light on the “known unknowns” of …
Allelic variation in class I HLA determines CD8+ T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2
JM Francis, D Leistritz-Edwards, A Dunn, C Tarr… - Science …, 2021 - science.org
Effective presentation of antigens by human leukocyte antigen (HLA) class I molecules to
CD8+ T cells is required for viral elimination and generation of long-term immunological …
CD8+ T cells is required for viral elimination and generation of long-term immunological …
Human leukocyte antigen complex and other immunogenetic and clinical factors influence susceptibility or protection to SARS-CoV-2 infection and severity of the …
R Littera, M Campagna, S Deidda, G Angioni… - Frontiers in …, 2020 - frontiersin.org
Aim SARS-CoV-2 infection is a world-wide public health problem. Several aspects of its
pathogenesis and the related clinical consequences still need elucidation. In Italy, Sardinia …
pathogenesis and the related clinical consequences still need elucidation. In Italy, Sardinia …
Association between HLA genotypes and COVID-19 susceptibility, severity and progression: a comprehensive review of the literature
The COVID-19 pandemic has markedly impacted on cultural, political, and economic
structures all over the world. Several aspects of its pathogenesis and related clinical …
structures all over the world. Several aspects of its pathogenesis and related clinical …
The influence of HLA genotype on the severity of COVID‐19 infection
The impact of COVID‐19 varies markedly, not only between individual patients but also
between different populations. We hypothesised that differences in HLA genes might …
between different populations. We hypothesised that differences in HLA genes might …
Increased risk of severe clinical course of COVID-19 in carriers of HLA-C* 04: 01
Background Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic,
there has been increasing urgency to identify pathophysiological characteristics leading to …
there has been increasing urgency to identify pathophysiological characteristics leading to …
HLA and AB0 polymorphisms may influence SARS-CoV-2 infection and COVID-19 severity
A Amoroso, P Magistroni, F Vespasiano, A Bella… - …, 2021 - journals.lww.com
Background. SARS-CoV-2 infection is heterogeneous in clinical presentation and disease
evolution. To investigate whether immune response to the virus can be influenced by …
evolution. To investigate whether immune response to the virus can be influenced by …
An effective COVID-19 vaccine needs to engage T cells
K Sauer, T Harris - Frontiers in immunology, 2020 - frontiersin.org
Ending the current COVID-19 pandemic and preventing recurrence requires the
development of vaccines that provide long-lasting immunity to the causative virus SARS …
development of vaccines that provide long-lasting immunity to the causative virus SARS …
Genome-wide B cell, CD4+, and CD8+ T cell epitopes that are highly conserved between human and animal coronaviruses, identified from SARS-CoV-2 as targets for …
S Prakash, R Srivastava, PG Coulon… - The Journal of …, 2021 - journals.aai.org
Over the last two decades, there have been three deadly human outbreaks of coronaviruses
(CoVs) caused by SARS-CoV, MERS-CoV, and SARS-CoV-2, which has caused the current …
(CoVs) caused by SARS-CoV, MERS-CoV, and SARS-CoV-2, which has caused the current …