Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …

Here we summarize the latest data on genetic and epigenetic contributions to human aging
and longevity. Whereas environmental and lifestyle factors are important at younger ages …

The maintenance of epigenetic characteristics is essential for the normal growth and
development of organisms. The maintenance of DNA methylation is an important way to …

Genetic and sporadic forms of tauopathies, the most prevalent of which is Alzheimer's
Disease, are a scourge of the aging society, and in the case of genetic forms, can also affect …

The balance of excitation and inhibition is essential for cortical information processing,
relying on the tight orchestration of the underlying subcellular processes. Dynamic …

Epigenetic mechanisms of gene regulation, including DNA methylation and histone
modifications, call increasing attention in the context of development and human health …

Increased life expectancy in modern society comes at the cost of age-associated disabilities
and diseases. Aged brains not only show reduced excitability and plasticity, but also a …

The limited regenerative capacity of neurons requires a tightly orchestrated cell death and
survival regulation in the context of longevity, as well as age-associated and …

The winter months are challenging for many animal species, which often enter a state of
dormancy or hypometabolism to “wait out” the cold weather, food scarcity, reduced daylight …

Apart from the conventional view of repressive promoter methylation, the DNA
methyltransferase 1 (DNMT1) was recently described to modulate gene expression through …