Viral and bacterial infections continue to pose significant challenges for numerous
individuals globally. To develop novel therapies to combat infections, more insight into the …

As alternative disease models, other than 2D cell lines and patient-derived xenografts,
organoids have preferable in vivo physiological relevance. However, both endogenous and …

Nanoplastics are prevalent in the air and can be easily inhaled, posing a threat to respiratory
health. However, there have been few studies investigating the impact of nanoplastics on …

Respiratory tissue engineering offers a robust framework for studying cell-cell and host-
pathogen interactions in a tissue-like environment and offers a platform for studying lung …

This critical review aims to highlight how modeling of the immune response has adapted
over time to utilize microphysiological systems. Topics covered here will discuss the integral …

Vascularized organoid-on-a-chip (VOoC) models achieve substance exchange in deep
layers of organoids and provide a more physiologically relevant system in vitro. Common …

Microphysiological systems (MPS) incorporate physiologically relevant microanatomy,
mechanics, and cells to mimic tissue function. Reproducible and standardized in vitro …

Organoids are three-dimensional in vitro models that recreate the structure and physiology
of their source organs or tissues in remarkable detail. Due to the diversity of organoids in …

Staphylococcus aureus (SA) pneumonia infections are widespread in Canada, particularly
in hospitalized patients, and are associated with high mortality rates and significant financial …