Background and aim Calprotectin (CLP) is a heterodimeric complex formed by two S100
proteins (S100A8/A9), which plays a pivotal role in innate immunity. Due to its intrinsic …

Neutrophils are vital for the innate immune system's control of pathogens and neutrophil
deficiency can render the host susceptible to life-threatening infections. Neutrophil …

Background Currently, it is not possible to predict whether patients with hyperuricemia
(HUA) will develop gout and how this progression may be affected by urate-lowering …

Objective Gout flares are followed by transient major cardiovascular (CV) risk, implicating
the role of inflammation; the aim of this study was to determine whether premature mortality …

Background and Objective Bone erosion is common in patients with gout. The role of
neutrophil-derived exosomes in gouty bone erosion remains elusive. This study aimed to …

Autophagy pathways play an important role in immunity and inflammation via pathogen
clearance mechanisms mediated by immune cells, such as macrophages and neutrophils …

The self-limiting nature of the inflammatory flare is a feature of gout. The effects of neutrophil
extracellular traps (NETs) on gout have remarkably attracted researchers' attention …

Objectives. To investigate the prevention and treatment effect of tanshinone IIA (TIIA) on
acute gouty arthritis (AGA) and its mechanism. Methods. The anti‐AGA effect of TIIA was …

Polygallic acid (PGAL) has been used in vitro to protect synoviocytes from monosodium
urate (MSU) crystals due to its anti-inflammatory properties. However, MSU crystals can also …

Objectives Microcrystal-induced arthritis is still an unresolved paradigm for medicine. Overt
inflammation may be absent even when crystals occur in SF. Recently, the production of …