Most cancers in humans are large, measuring centimetres in diameter, and composed of many billions of cells. An equivalent mass of normal cells would be highly heterogeneous as …
Cancer growth can be described as a caricature of the renewal process of the tissue of origin, where the tissue architecture has a strong influence on the evolutionary dynamics …
K Kaveh, NL Komarova… - Royal Society open …, 2015 - royalsocietypublishing.org
Evolutionary models on graphs, as an extension of the Moran process, have two major implementations: birth–death (BD) models (or the invasion process) and death–birth (DB) …
Natural selection is usually studied between mutants that differ in reproductive rate, but are subject to the same population structure. Here we explore how natural selection acts on …
W Postek, K Staśkiewicz, E Lilja… - Proceedings of the …, 2024 - National Acad Sciences
Biofilms inhabit a range of environments, such as dental plaques or soil micropores, often characterized by noneven surfaces. However, the impact of surface irregularities on the …
A growing body of evidence suggests that a subset of human cancers grows as single clonal expansions. In such a nearly neutral evolution scenario, it is possible to infer the early …
Spatial heterogeneity plays an important role in the evolution of drug resistance. While recent studies have indicated that spatial gradients of selection pressure can accelerate …
Numerous experimental studies have demonstrated that the microenvironment is a key regulator influencing the proliferative and migrative potentials of species. Spatial and …
T Monk, A van Schaik - Royal Society Open Science, 2021 - royalsocietypublishing.org
Evolutionary graph theory investigates how spatial constraints affect processes that model evolutionary selection, eg the Moran process. Its principal goals are to find the fixation …