8-Oxoguanine: from oxidative damage to epigenetic and epitranscriptional modification

JY Hahm, J Park, ES Jang, SW Chi - Experimental & molecular …, 2022 - nature.com
In pathophysiology, reactive oxygen species control diverse cellular phenotypes by
oxidizing biomolecules. Among these, the guanine base in nucleic acids is the most …

The international society of RNA nanotechnology and nanomedicine (ISRNN): the present and future of the burgeoning field

M Chandler, B Johnson, E Khisamutdinov… - ACS …, 2021 - ACS Publications
The International Society of RNA Nanotechnology and Nanomedicine (ISRNN) hosts an
annual meeting series focused on presenting the latest research achievements involving …

Exposure to urban nanoparticles at low PM concentrations as a source of oxidative stress and inflammation

F Costabile, M Gualtieri, M Rinaldi, S Canepari… - Scientific Reports, 2023 - nature.com
Exposures to fine particulate matter (PM 1) have been associated with health impacts, but
the understanding of the PM 1 concentration-response (PM 1-CR) relationships, especially …

Mapping the future of oxidative RNA damage in neurodegeneration: Rethinking the status quo with new tools

HB Wheeler, AA Madrigal, IA Chaim - … of the National Academy of Sciences, 2024 - pnas.org
Over two decades ago, increased levels of RNA oxidation were reported in postmortem
patients with ALS, Alzheimer's, Parkinson's, and other neurodegenerative diseases …

Selective 8-oxo-rG stalling occurs in the catalytic core of polynucleotide phosphorylase (PNPase) during degradation

LG Miller, W Kim, S Schowe, K Taylor, R Han… - Proceedings of the …, 2024 - pnas.org
RNA oxidation, predominantly through the accumulation of 8-oxo-7, 8-dihydroguanosine (8-
oxo-rG), represents an important biomarker for cellular oxidative stress. Polynucleotide …

Formation of oxidized gases and secondary organic aerosol from a commercial oxidant-generating electronic air cleaner

T Joo, JC Rivera-Rios, D Alvarado-Velez… - … & Technology Letters, 2021 - ACS Publications
The COVID-19 pandemic increased the demand for indoor air cleaners. While some
commercial electronic air cleaners can be effective in reducing primary pollutants and …

FDFT1 repression by piR-39980 prevents oncogenesis by regulating proliferation and apoptosis through hypoxia in tongue squamous cell carcinoma

T Chattopadhyay, B Mallick - Life Sciences, 2023 - Elsevier
Aim Tongue squamous cell carcinoma (TSCC) is one of the most aggressive tumors whose
underlying molecular mechanism remains elusive. Previous studies have identified piR …

Particulate matter composition drives differential molecular and morphological responses in lung epithelial cells

SM Engels, P Kamat, GS Pafilis, Y Li, A Agrawal… - PNAS …, 2024 - academic.oup.com
Particulate matter (PM) is a ubiquitous component of air pollution that is epidemiologically
linked to human pulmonary diseases. PM chemical composition varies widely, and the …

Pathogenic mechanisms of secondary organic aerosols

T Déméautis, M Delles, S Tomaz… - Chemical Research …, 2022 - ACS Publications
Air pollution represents a major health problem and an economic burden. In recent years,
advances in air pollution research has allowed particle fractionation and identification of …

RNA oxidation in chromatin modification and DNA-damage response following exposure to formaldehyde

JC Gonzalez-Rivera, MW Sherman, DS Wang… - Scientific Reports, 2020 - nature.com
Formaldehyde is an environmental and occupational chemical carcinogen implicated in the
damage of proteins and nucleic acids. However, whether formaldehyde provokes …