The liver, a component of the gastrointestinal tract, is one of the most important organs in the
human body. The liver performs over 500 functions to promote physiological homeostasis. In …

Bile duct obstruction is a potent stimulus for cholangiocyte proliferation, especially for large
cholangiocytes. Our previous studies reported that conjugated bile acids (CBAs) activate the …

Idiosyncratic drug‐induced liver injury (DILI) is a rare, often difficult‐to‐predict adverse
reaction with complex pathomechanisms. However, it is now evident that certain forms of …

An accurate tool enabling early diagnosis of hepatocellular carcinoma (HCC) is clinically
important, given that early detection of HCC markedly improves survival. We aimed to …

Impaired intestinal barrier function promotes the progression of various liver diseases,
including cholestatic liver diseases. The close association of primary sclerosing cholangitis …

Deregulation of the immune system is believed to contribute to cancer malignancy, which
has led to recent therapeutic breakthroughs facilitating antitumor immunity. In a malignant …

Background Pancreatic cancer (PC) has an extremely high mortality rate, where obstructive
jaundice due to cholestasis is a classic symptom. Conjugated bile acids (CBAs) such as …

Abstract Patient-Derived Xenograft (PDX) is now accepted as a murine model that better
mimics human cancer when compared to a conventional cancer cell-line inoculation model …

Background Doxorubicin is one of the most commonly used chemotherapeutic drugs for
breast cancer; however, its use is limited by drug resistance and side effects. We …

The aim of this study was to assess the patterns and pattern disruptions of free radical
processes in patients with obstructive jaundice of various origins, and the severity of …