Tumor tissue is composed of cancer cells and surrounding stromal cells with diverse
genetic/epigenetic backgrounds, a situation known as intra-tumoral heterogeneity. Cancer …

Simple Summary Reprogramming of glucose metabolism is a hallmark of cancer and can be
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …

Ionizing radiation (IR) activates both pro-and anti-proliferative signal pathways producing an
imbalance in cell fate decision. IR is able to regulate several genes and factors involved in …

Tumourigenic tissue uses modified metabolic signalling pathways in order to support
hyperproliferation and survival. Cancer-associated aerobic glycolysis resulting in lactic acid …

Introduction Osteoarthritis (OA) is considered to be a multifactorial and polygenic disease
and diagnosis is mainly clinical and radiological. Correlation between radiographic data and …

Colorectal cancer (CRC) ranks the third most commonly diagnosed cancer in males and the
second in females worldwide. However, the functional and causal SNPs for CRC remain to …

Abstract Glucose regulated protein 78 (GRP 78), a master regulator of endoplasmic
reticulum stress has been reported to be up regulated in various cancers and remains a …

Background/Aim: Epithelial–mesenchymal transition (EMT) is a process co-opted by cancer
cells to invade and form metastases. In the present study we analyzed gene expression …

Background: There is extensive scientific evidence that radiation therapy (RT) is a crucial
treatment, either alone or in combination with other treatment modalities, for many types of …

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) is a member of a family of
peptidyl-prolyl isomerases that specifically recognizes and binds phosphoproteins …