How chromosomal inversions reorient the evolutionary process
Inversions are structural mutations that reverse the sequence of a chromosome segment
and reduce the effective rate of recombination in the heterozygous state. They play a major …
and reduce the effective rate of recombination in the heterozygous state. They play a major …
[HTML][HTML] Recurrent inversion polymorphisms in humans associate with genetic instability and genomic disorders
Unlike copy number variants (CNVs), inversions remain an underexplored genetic variation
class. By integrating multiple genomic technologies, we discover 729 inversions in 41 …
class. By integrating multiple genomic technologies, we discover 729 inversions in 41 …
[HTML][HTML] Deciphering the role of structural variation in human evolution: a functional perspective
Advances in sequencing technologies have enabled the comparison of high-quality
genomes of diverse primate species, revealing vast amounts of divergence due to structural …
genomes of diverse primate species, revealing vast amounts of divergence due to structural …
[HTML][HTML] Chromosomal inversion polymorphisms shape human brain morphology
The impact of chromosomal inversions on human brain morphology remains underexplored.
We studied 35 common inversions classified from genotypes of 33,018 adults with European …
We studied 35 common inversions classified from genotypes of 33,018 adults with European …
Complete sequencing of ape genomes
We present haplotype-resolved reference genomes and comparative analyses of six ape
species, namely: chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan …
species, namely: chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan …
Stepwise evolution of a butterfly supergene via duplication and inversion
KW Kim, R De-Kayne, IJ Gordon… - … of the Royal …, 2022 - royalsocietypublishing.org
Supergenes maintain adaptive clusters of alleles in the face of genetic mixing. Although
usually attributed to inversions, supergenes can be complex, and reconstructing the precise …
usually attributed to inversions, supergenes can be complex, and reconstructing the precise …
Adaptive functions of structural variants in human brain development
W Ding, X Li, J Zhang, M Ji, M Zhang, X Zhong… - Science …, 2024 - science.org
Quantifying the structural variants (SVs) in nonhuman primates could provide a niche to
clarify the genetic backgrounds underlying human-specific traits, but such resource is largely …
clarify the genetic backgrounds underlying human-specific traits, but such resource is largely …
Divergence and gene flow history at two large chromosomal inversions underlying ecotype differentiation in the long‐snouted seahorse
Chromosomal inversions can play an important role in divergence and reproductive
isolation by building and maintaining distinct allelic combinations between evolutionary …
isolation by building and maintaining distinct allelic combinations between evolutionary …
Structural Variation Evolution at the 15q11-q13 Disease-Associated Locus
A Paparella, A L'Abbate, D Palmisano… - International Journal of …, 2023 - mdpi.com
The impact of segmental duplications on human evolution and disease is only just starting to
unfold, thanks to advancements in sequencing technologies that allow for their discovery …
unfold, thanks to advancements in sequencing technologies that allow for their discovery …
Genomic structural variation: A complex but important driver of human evolution
Structural variants (SVs)—including duplications, deletions, and inversions of DNA—can
have significant genomic and functional impacts but are technically difficult to identify and …
have significant genomic and functional impacts but are technically difficult to identify and …