Matrix metalloproteinases promote arterial remodeling in aging, hypertension, and atherosclerosis
MMP activation plays a causal role in the elastogenesis (production) and elastolysis
(degradation) in the arterial wall (Figure; Table). Elastin fibers are effectively digested by …
(degradation) in the arterial wall (Figure; Table). Elastin fibers are effectively digested by …
Rational chemical design of the next generation of molecular imaging probes based on physics and biology: mixing modalities, colors and signals
H Kobayashi, MR Longmire, M Ogawa… - Chemical Society …, 2011 - pubs.rsc.org
In recent years, numerous in vivo molecular imaging probes have been developed. As a
consequence, much has been published on the design and synthesis of molecular imaging …
consequence, much has been published on the design and synthesis of molecular imaging …
Matrix metalloproteinase inhibition therapy for vascular diseases
AC Newby - Vascular pharmacology, 2012 - Elsevier
The matrix metalloproteinases (MMPs) are 23 secreted or cell surface proteases that act
together and with other protease classes to turn over the extracellular matrix, cleave cell …
together and with other protease classes to turn over the extracellular matrix, cleave cell …
Current status of medical management for abdominal aortic aneurysm
J Golledge, PE Norman - Atherosclerosis, 2011 - Elsevier
Previous trials indicate that surgical management of small abdominal aortic aneurysms
(AAA) does not reduce mortality. The medical management of AAA, however, has to a large …
(AAA) does not reduce mortality. The medical management of AAA, however, has to a large …
Matrix metalloproteinases in non-neoplastic disorders
A Tokito, M Jougasaki - International journal of molecular sciences, 2016 - mdpi.com
The matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases belonging to the
metzincin superfamily. There are at least 23 members of MMPs ever reported in human, and …
metzincin superfamily. There are at least 23 members of MMPs ever reported in human, and …
The calcium chloride-induced rodent model of abdominal aortic aneurysm
Abdominal aortic aneurysm (AAA) affects∼ 5% men aged over 65 years and is an important
cause of death in this population. Research into AAA pathogenesis has been fuelled by the …
cause of death in this population. Research into AAA pathogenesis has been fuelled by the …
The contribution of matrix metalloproteinases and their inhibitors to the development, progression, and rupture of abdominal aortic aneurysms
G Atkinson, R Bianco, K Di Gregoli… - Frontiers in …, 2023 - frontiersin.org
Abdominal aortic aneurysms (AAAs) account for up to 8% of deaths in men aged 65 years
and over and 2.2% of women. Patients with AAAs often have atherosclerosis, and intimal …
and over and 2.2% of women. Patients with AAAs often have atherosclerosis, and intimal …
Parametric study of effects of collagen turnover on the natural history of abdominal aortic aneurysms
Abdominal aortic aneurysms (AAAs) are characterized by significant changes in the
architecture of the aortic wall, notably, loss of functional elastin and smooth muscle. Because …
architecture of the aortic wall, notably, loss of functional elastin and smooth muscle. Because …
Molecular imaging of aortic aneurysm and its translational power for clinical risk assessment
V Rastogi, SJM Stefens, J Houwaart… - Frontiers in …, 2022 - frontiersin.org
Aortic aneurysms (AAs) are dilations of the aorta, that are often fatal upon rupture.
Diagnostic radiological techniques such as ultrasound (US), magnetic resonance imaging …
Diagnostic radiological techniques such as ultrasound (US), magnetic resonance imaging …
Molecular imaging of macrophage protease activity in cardiovascular inflammation in vivo
Macrophages contribute pivotally to cardiovascular diseases (CVD), notably to
atherosclerosis. Imaging of macrophages in vivo could furnish new tools to advance …
atherosclerosis. Imaging of macrophages in vivo could furnish new tools to advance …