Herpes simplex viruses are ubiquitous human pathogens represented by two distinct
serotypes: herpes simplex virus (HSV) type 1 (HSV-1); and HSV type 2 (HSV-2). In the …

Cancer remains a serious threat to human health, causing over 500 000 deaths each year in
US alone, exceeded only by heart diseases. Many new technologies are being developed to …

Naturally occurring CD4+ CD25+ regulatory T cells appear important to prevent activation of
autoreactive T cells. This article demonstrates that the magnitude of a CD8+ T cell–mediated …

Herpes simplex virus type 1 (HSV-1) infection of the murine cornea induces the rapid
infiltration of neutrophils. We investigated whether these cells could influence virus …

In this communication, we demonstrate that galectin (Gal)-9 acts to constrain CD8+ T cell
immunity to Herpes Simplex Virus (HSV) infection. In support of this, we show that animals …

We have examined the generation of CTL immunity immediately after localized footpad
infection with herpes simplex virus 1 (HSV-1) using three coordinated in vivo T cell tracking …

Intravaginal inoculation of mice with an attenuated strain of herpes simplex virus type 2
(HSV-2) resulted in vigorous HSV-specific immune responses that protected against …

CTL play a major role in immunity to HSV type 1, but little is known about the priming
process. In this study, we have examined the class I-restricted presentation of an …

Many virus infections give rise to surprisingly limited T-cell responses directed to very few
immunodominant determinants. We have been examining the cytotoxic T-lymphocyte (CTL) …

We have constructed recombinant baculoviruses individually expressing seven of the
herpes simplex virus type 1 (HSV-1) glycoproteins (gB, gC, gD, gE, gG, gH, and gI) …