Targeting calcium homeostasis in myocardial ischemia/reperfusion injury: an overview of regulatory mechanisms and therapeutic reagents

R Wang, M Wang, S He, G Sun, X Sun - Frontiers in pharmacology, 2020 - frontiersin.org
Calcium homeostasis plays an essential role in maintaining excitation–contraction coupling
(ECC) in cardiomyocytes, including calcium release, recapture, and storage. Disruption of …

Functional diversification and structural origins of plant natural product methyltransferases

A Lashley, R Miller, S Provenzano, SA Jarecki, P Erba… - Molecules, 2022 - mdpi.com
In plants, methylation is a common step in specialized metabolic pathways, leading to a vast
diversity of natural products. The methylation of these small molecules is catalyzed by S …

A Combinatorial Approach to Optimize the Production of Curcuminoids From Tyrosine in Escherichia coli

JL Rodrigues, D Gomes, LR Rodrigues - Frontiers in Bioengineering …, 2020 - frontiersin.org
Curcuminoids are well-known for their therapeutic properties. However, their extraction from
natural sources is environmentally unfriendly, expensive and limited by seasonal variability …

Evaluating the therapeutic efficiency and drug targeting ability of alkaloids present in Rauwolfia serpentina

M Singh - International Journal of Green Pharmacy (IJGP), 2017 - greenpharmacy.info
Rauwolfia serpentina is reported in an Ayurvedic medicinal system for centuries, for the
treatment of various ailments such as snakebites, insomnia, hypertension, and insanity …

Defining the role of a caffeic acid 3-O-methyltransferase from Azadirachta indica fruits in the biosynthesis of ferulic acid through heterologous over-expression in …

LK Narnoliya, N Sangwan, JS Jadaun, S Bansal… - Planta, 2021 - Springer
Main conclusion The recombinant caffeic acid 3-O-methyltransferase gene has been cloned
and characterized from Neem. The gene is involved in ferulic acid biosynthesis, a key …

Biosynthesis of elemicin and isoelemicin in Daucus carota leaves

XQ Huang, M Yahyaa, PR Kongala, I Maoz… - The Plant …, 2025 - Wiley Online Library
Volatile phenylpropenes comprise one of the largest groups of plant phenylalanine‐derived
volatiles that not only possess ecological roles but also exhibit numerous pharmacological …

Identification of C-glycosyl flavones by high performance liquid chromatography electrospray ionization mass spectrometry and quantification of five main C-glycosyl flavones in …

Y Wang, Z Liang, X Liao, C Zhou, Z Xie, S Zhu, G Wei… - BMC chemistry, 2019 - Springer
Flickingeria fimbriata is commonly applied in China as a traditional Chinese medicine
(TCM), however the quality control of it is incomplete. In this work, we aim to identify and …

A novel O-methyltransferase Cp4MP-OMT catalyses the final step in the biosynthesis of the volatile 1,4-dimethoxybenzene in pumpkin (Cucurbita pepo) flowers

MC Hoepflinger, M Barman, S Dötterl, R Tenhaken - BMC Plant Biology, 2024 - Springer
Background Floral scents play a crucial role in attracting insect pollinators. Among the
compounds attractive to pollinators is 1, 4-dimethoxybenzene (1, 4-DMB). It is a significant …

Rauwolfia serpentina

K Shitiz, SP Gupta - Himalayan Medicinal Plants, 2021 - Elsevier
Abstract Rauwolfia serpentina (L.) Benth. ex Kurz. also known as Indian snakeroot is an
endangered medicinal shrub which belongs to the Apocynaceae family. It possesses …

Mycobacterial MMAR_2193 catalyzes O-methylation of diverse polyketide cores

GR Giri, P Saxena - Plos one, 2022 - journals.plos.org
O-methylation of small molecules is a common modification widely present in most
organisms. Type III polyketides undergo O-methylation at hydroxyl end to play a wide …