[HTML][HTML] Recent trends and advances in type 1 diabetes therapeutics: A comprehensive review

A Singh, N Afshan, A Singh, SK Singh, S Yadav… - European journal of cell …, 2023 - Elsevier
Abstract Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the
destruction of pancreatic β-cells, leading to insulin deficiency. Insulin replacement therapy is …

Mitigation of the hyperglycemic effect of streptozotocin-induced diabetes albino rats using biosynthesized copper oxide nanoparticles

AS Hussein, AH Hashem, SS Salem - Biomolecular Concepts, 2023 - degruyter.com
Diabetes mellitus is a metabolic disorder described by compromised insulin synthesis or
resistance to insulin inside the human body. Diabetes is a persistent metabolic condition …

Amelioration of diabetic nephropathy in mice by a single intravenous injection of human mesenchymal stromal cells at early and later disease stages is associated …

J He, B Liu, X Du, Y Wei, D Kong, B Feng… - Stem Cell Research & …, 2024 - Springer
Background and aims Mesenchymal stromal cells (MSCs) a potentially effective disease-
modulating therapy for diabetic nephropathy (DN) but their clinical translation has been …

Bone marrow stem cell-derived β-cells: new issue for diabetes cell therapy

HA Aglan, SE Kotob, NS Mahmoud, MS Kishta… - Tissue and Cell, 2024 - Elsevier
This investigation aimed to establish the promising role of insulin-producing cells (IPCs)
growing from bone marrow-mesenchymal stem cells (BM-MSCs) in relieving hyperglycemia …

Enhanced Insulin Secretion Through Upregulation of Transcription Factors by Hydroalcoholic Extract of Securigera securidaca Seeds in Diabetic Animal Model

M Hasani, E Abbasi‐Oshaghi, F Khomari… - Endocrinology …, 2024 - Wiley Online Library
Aim In previous studies, the researchers observed an increase in insulin secretion in STZ‐
treated diabetic rats following treatment with the hydroalcoholic extract of Securigera …

Protective effect of mesenchymal stromal cells in diabetic nephropathy: the In vitro and In vivo role of the M-Sec-tunneling nanotubes

F Barutta, B Corbetta, S Bellini, R Gambino… - Clinical …, 2024 - portlandpress.com
Mitochondrial dysfunction plays an important role in the development of podocyte injury in
diabetic nephropathy (DN). Tunnelling nanotubes (TNTs) are long channels that connect …

The effect of diabetes mellitus on differentiation of mesenchymal stem cells into insulin-producing cells

OI Badr, MM Kamal, SA El-Maraghy, HR Ghaiad - Biological Research, 2024 - Springer
Background Diabetes mellitus (DM) is a global epidemic with increasing incidences. DM is a
metabolic disease associated with chronic hyperglycemia. Aside from conventional …

Wharton's Jelly Mesenchymal Stem Cell Conditioned Medium Ameliorates Diabetes‐Induced Testicular Damage and Sperm Abnormalities by Mitigating Oxidative …

M Sargazi, N Karbalaei, S Karbalay-Doust… - Stem Cells …, 2024 - Wiley Online Library
Diabetes leads to testicular damage and infertility. Mesenchymal stem cells and their
secretory trophic factors have shown potential as regenerative therapies for diabetes and its …

Novel lipid mediator 7S,14R-docosahexaenoic acid: biogenesis and harnessing mesenchymal stem cells to ameliorate diabetic mellitus and retinal pericyte loss

Y Lu, H Tian, H Peng, Q Wang, BA Bunnell… - Frontiers in Cell and …, 2024 - frontiersin.org
Introduction: Stem cells can be used to treat diabetic mellitus and complications. ω3-
docosahexaenoic acid (DHA) derived lipid mediators are inflammation-resolving and …

Differential effects of liraglutide naltrexone/bupropion, and caloric restriction on metabolic parameters and beta-cell regeneration in type 2 diabetic rat model: role of …

DH Merzeban, AM El Amin Ali, RO Hammad… - Journal of Molecular …, 2025 - Springer
Traditional antidiabetic treatments often carry the risk of beta-cell exhaustion, highlighting
the need for therapies that promote beta-cell regeneration. This study investigates the …