Polypeptide-based systems: From synthesis to application in drug delivery

M Stepanova, A Nikiforov, T Tennikova… - Pharmaceutics, 2023 - mdpi.com
Synthetic polypeptides are biocompatible and biodegradable macromolecules whose
composition and architecture can vary over a wide range. Their unique ability to form …

Nanocarriers for targeted drug delivery in the vascular system: Focus on endothelium

X Cong, Z Zhang, H Li, YG Yang, Y Zhang… - Journal of …, 2024 - Springer
Endothelial cells (ECs) are pivotal in maintaining vascular health, regulating hemodynamics,
and modulating inflammatory responses. Nanocarriers hold transformative potential for …

Highly scalable and standardized organ-on-chip platform with TEER for biological barrier modeling

HT Nguyen, SL Rissanen, M Peltokangas… - Tissue …, 2024 - Taylor & Francis
The development of new therapies is hampered by the lack of predictive, and patient-
relevant in vitro models. Organ-on-chip (OOC) technologies can potentially recreate …

Navigating the neurological frontier: Macromolecular marvels in overcoming blood-brain barrier challenges for advanced drug delivery

E Zeynalzadeh, E Khodadadi, E Khodadadi… - Heliyon, 2024 - cell.com
The blood-brain interface poses formidable obstacles in addressing neurological conditions
such as Alzheimer's, Multiple Sclerosis, brain cancers, and cerebrovascular accidents …

Hydrogelation of polypeptide-poly (ethylene glycol)-polypeptide amphiphilic triblock copolymers using L-cysteine derivatives

THM Phan, XH Chen, ST Huang, JS Jan - European Polymer Journal, 2023 - Elsevier
The hydrogelation of amphiphilic triblock copolymers based on the poly (ethylene
glycol)(PEG) and the sheet-like polypeptides was studied in this report. The triblock …

Targeting peripheral N-Methyl-D-Aspartate Receptor (NMDAR): A novel strategy for the treatment of migraine

V Kalatharan, MAM Al-Karagholi - Journal of Clinical Medicine, 2023 - mdpi.com
Backgrounds: Several acute and preventive medications were developed for the treatment
of migraine. Yet, a significant proportion of patients reports an inadequate response and a …

Current emerging novel therapies for Alzheimer's disease and the future prospects of magneto-mechanical force therapy

Y Shen, M Wang, S Li, J Yang - Journal of Materials Chemistry B, 2023 - pubs.rsc.org
Alzheimer's disease (AD) is the most common neurodegenerative disease among the
elderly, and the morbidity increases with the aging population aggravation. The clinical …

Synergistic induction of blood–brain barrier properties

G Porkoláb, M Mészáros, A Szecskó… - Proceedings of the …, 2024 - National Acad Sciences
Blood–brain barrier (BBB) models derived from human stem cells are powerful tools to
improve our understanding of cerebrovascular diseases and to facilitate drug development …

[HTML][HTML] Nanogel-Mediated Therapeutic Delivery Across Blood-Cerebrospinal Fluid and Blood-Spinal Cord Barriers

DM Modi, AD Modi - Brain Disorders, 2024 - Elsevier
Nanogels are emerging as promising nanocarriers for delivering therapeutic agents to treat
central nervous system (CNS) disorders. Traditional therapeutic approaches for CNS …

Design, Optimization, and Application of a 3D-Printed Polymer Sample Introduction System for the ICP-MS Analysis of Nanoparticles and Cells

G Kajner, Á Bélteki, M Cseh, Z Geretovszky, T Ajtai… - Nanomaterials, 2023 - mdpi.com
Commonly used sample introduction systems for inductively coupled plasma mass
spectrometry (ICP-MS) are generally not well-suited for single particle ICP-MS (spICP-MS) …