Mechanical forces shape biological tissues. They are the effectors of the developmental
programs that orchestrate morphogenesis. A lot of effort has been devoted to understanding …

Of fundamental interest to biologists is how organs achieve a reproducible size during
development. Studies of the developing Drosophila wing have provided many key insights …

During development, coordinated cell behaviors orchestrate tissue and organ
morphogenesis. Detailed descriptions of cell lineages and behaviors provide a powerful …

Mechanical stress can influence cell proliferation in vitro, but whether it makes a significant
contribution to growth control in vivo, and how it is modulated and experienced by cells …

Quantitative analysis of the dynamic cellular mechanisms shaping the Drosophila wing
during its larval growth phase has been limited, impeding our ability to understand how …

Scanning fluorescence microscopes are now able to image large biological samples at high
spatial and temporal resolution. This comes at the expense of an increased light dose which …

Multicellular model organisms, such as Drosophila melanogaster (fruit fly), are frequently
used in a myriad of biological research studies due to their biological significance and …

One of the fundamental questions in developmental biology is what determines the final size
and shape of an organ. Recent research strongly emphasizes that besides cell-cell …

The Drosophila larva has been used to investigate many processes in cell biology, including
morphogenesis, physiology and responses to drugs and new therapeutic compounds …

The question of how the physical dimensions of animal organs are specified has long
fascinated both experimentalists and computational scientists working in the field of …