Oncogene activation and tumor-suppressor gene inactivation are considered as the main
causes driving the transformation of normal somatic cells into malignant tumor cells. Cancer …

Metastasis is a multistage process that requires cancer cells to escape from the primary
tumour, survive in the circulation, seed at distant sites and grow. Each of these processes …

Angiogenesis inhibitors targeting the vascular endothelial growth factor (VEGF) signalling
pathways are affording demonstrable therapeutic efficacy in mouse models of cancer and in …

The dependency of the growth of tumors on blood vessels, once considered a doubtful
proposition, has become a major avenue of research and drug development. This review …

The use of various transgenic mouse models and analysis of human tumour biopsies has
shown that bone marrow-derived myeloid cells, such as macrophages, neutrophils …

Several vascular endothelial growth factor (VEGF)-targeted agents, administered either as
single agents or in combination with chemotherapy, have been shown to benefit patients …

The blood-brain barrier (BBB) maintains brain homeostasis and limits the entry of toxins and
pathogens into the brain. Despite its importance, little is known about the molecular …

Coined in the late eighties, the term “angiogenic switch” refers to a time-restricted event
during tumor progression where the balance between pro-and anti-angiogenic factors tilts …

Using MRI techniques, we show here that normalization of tumor vessels in recurrent
glioblastoma patients by daily administration of AZD2171—an oral tyrosine kinase inhibitor …

Glioblastoma (GBM) is the most malignant brain tumor and is highly resistant to intensive
combination therapies and anti-VEGF therapies. To assess the resistance mechanism to anti …