Recent advancements in synthetic methodologies of 3-substituted phthalides and their application in the total synthesis of biologically active natural products

A Awasthi, M Singh, G Rathee, R Chandra - RSC advances, 2020 - pubs.rsc.org
We have provided a critical review that focuses on key developments in the area of 3-
substituted phthalides and their role in the development of important biologically active …

Catalytic asymmetric synthesis of isoindolinones

W Gao, M Chen, Q Ding, Y Peng - Chemistry–An Asian Journal, 2019 - Wiley Online Library
As important reactive species, isoindolinones represent a cluster of valuable building blocks
for the construction of natural‐product‐like compounds. In particular, chiral isoindolinones …

Divergent synthesis of tunable cyclopentadienyl ligands and their application in Rh-catalyzed enantioselective synthesis of isoindolinone

WJ Cui, ZJ Wu, Q Gu, SL You - Journal of the American Chemical …, 2020 - ACS Publications
A series of rhodium complexes bearing sterically and electronically tunable
cyclopentadienyl ligands, prepared by utilizing Co2 (CO) 8-mediated [2+ 2+ 1] cyclization as …

Photoredox‐Enabled Self‐(3+2) Cyclization of Vinyldiazo Reagents: Synthesis of Cyclopentenyl α‐Diazo Compounds

W Li, S Li, C Empel, RM Koenigs… - Angewandte Chemie …, 2023 - Wiley Online Library
Abstract A photocatalytic self‐(3+ 2) cycloaddition of vinyldiazo compounds is described,
which provides cyclopentene derivatives with conservation of one diazo functional group …

Electrochemical Difunctionalization of Olefines: Access to Selenomethyl‐Substituted Cyclic Ethers or Lactones

XJ Meng, PF Zhong, YM Wang… - Advanced Synthesis …, 2020 - Wiley Online Library
A metal‐and oxidant‐free electrochemical method for preparing selenomethyl‐substituted
cyclic ethers or lactones via difunctionalization of olefines is presented. A series of …

Synergistic Visible Light and Pd-Catalyzed C–H Alkylation of 1-Naphthylamines with α-Diazoesters

B Zhao, H Li, F Jiang, JP Wan, K Cheng… - The Journal of Organic …, 2022 - ACS Publications
The combination of visible light irradiation and Pd-catalysis has been practically employed
for the C–H alkylation reactions of naphthylamines and α-diazo esters, leading to the …

Direct synthesis of chiral NH lactams via Ru-catalyzed asymmetric reductive amination/cyclization cascade of keto acids/esters

Y Shi, X Tan, S Gao, Y Zhang, J Wang, X Zhang… - Organic …, 2020 - ACS Publications
Lactams with a stereogenic center adjacent to the N atom have existed in many medicinal
agents and bioactive alkaloids. Herein we report a broadly applicable synthesis of …

Rhodium (III)-Catalyzed Asymmetric Addition of Inert Arene C–H Bond to Aldehydes To Afford Enantioenriched Phthalides

W Chen, J Li, H Xie, J Wang - Organic letters, 2020 - ACS Publications
An asymmetric rhodium (III)-catalyzed Grignard-type addition of inert arene C–H bond to
aldehydes is reported. It provides a new strategy for the synthesis of chiral 3-substituted …

Synthesis of 3-Hydroxymethyl Isoindolinones via Cobalt-Catalyzed C(sp2)–H Carbonylation of Phenylglycinol Derivatives

L Lukasevics, A Cizikovs, L Grigorjeva - Organic letters, 2020 - ACS Publications
An efficient method for the synthesis of 3-hydroxymethyl isoindolinones via cobalt-catalyzed
C (sp2)–H carbonylation of phenylglycinol derivatives using picolinamide as a traceless …

Recent Advancement in H8–BINOL Catalyzed Asymmetric Methodologies

R Kshatriya - ACS omega, 2023 - ACS Publications
H8–BINOL, a partially reduced form of BINOL, is widely employed in a broad array of
organocatalyzed asymmetric methodologies. Over the last 25 years, asymmetric …