Ischemia-reperfusion injury is associated with serious clinical manifestations, including
myocardial hibernation, acute heart failure, cerebral dysfunction, gastrointestinal …

Reactive oxygen species (ROS)-dependent production of ROS underlies sustained
oxidative stress, which has been implicated in the pathogenesis of cardiovascular diseases …

Nitric oxide (NO) is one of the most important molecules released by endothelial cells, and
its antiatherogenic properties support cardiovascular homeostasis. Diminished NO …

Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …

Reperfusion injury, the paradoxical tissue response that is manifested by blood flow-
deprived and oxygen-starved organs following the restoration of blood flow and tissue …

Cardiovascular diseases are major contributors to global deaths and disability‐adjusted life
years, with hypertension a significant risk factor for all causes of death. The endothelium that …

Half of patients with heart failure (HF) have a preserved left ventricular ejection fraction
(HFpEF). Morbidity and mortality in HFpEF are similar to values observed in patients with HF …

Based on the “free radical theory” of disease, researchers have been trying to elucidate the
role of oxidative stress from free radicals in cardiovascular disease. Considerable data …

Acute and chronic excessive intracellular increase of reactive oxygen species (ROS) is
involved in the development and progression of cardiovascular diseases. ROS are by …

Nitric oxide (radical dot NO) is synthetized enzymatically from l-arginine (l-Arg) by three NO
synthase isoforms, iNOS, eNOS and nNOS. The synthesis of NO is selectively inhibited by …