In vivo studies represent an essential step in drug development and currently rely largely on
mice, yet limitations of mammalian models motivated the search for complementary …

The lack of correlative and predictive models to assess acute and chronic toxicities limits the
rapid pre-clinical development of new therapeutics. This barrier is due in part to the …

Zebrafish are becoming increasingly popular as an organism in which to model human
disease and to study the effects of small molecules on complex physiological and …

Saccharomyces cerevisiae is used to provide fundamental understanding of eukaryotic
genetics, gene product function, and cellular biological processes. Saccharomyces Genome …

Quantum dots (QDs) hold promise for several biomedical, life sciences, and photovoltaic
applications. Substantial production volumes and environmental release are anticipated. QD …

The search for novel anticonvulsants requires appropriate model systems in which to test
hypotheses through focused compound screening or genetic manipulation, or conduct black …

Mechanotransduction pathways are activated in response to biophysical stimuli during the
development or homeostasis of organs and tissues. In zebrafish, the blood-flow-sensitive …

Biological molecules and intracellular structures operate at the nanoscale; therefore,
development of nanomedicines shows great promise for the treatment of disease by using …

The zebrafish (Danio rerio) is an established model organism for the study of developmental
processes, human disease, and tissue regeneration. We report that limb regeneration is …

Acute lymphoblastic leukemia (ALL) is a clonal disease that evolves through the accrual of
genetic rearrangements and/or mutations within the dominant clone. The TEL-AML1 (ETV6 …