Glut1 Deficiency Syndrome (Glut1DS): State of the art in 2020 and recommendations of the international Glut1DS study group

J Klepper, C Akman, M Armeno, S Auvin… - Epilepsia …, 2020 - Wiley Online Library
Glut1 deficiency syndrome (Glut1DS) is a brain energy failure syndrome caused by impaired
glucose transport across brain tissue barriers. Glucose diffusion across tissue barriers is …

[HTML][HTML] Structure, function and regulation of mammalian glucose transporters of the SLC2 family

GD Holman - Pflügers Archiv-European Journal of Physiology, 2020 - Springer
The SLC2 genes code for a family of GLUT proteins that are part of the major facilitator
superfamily (MFS) of membrane transporters. Crystal structures have recently revealed how …

An investigation on the molecular structure, interaction with metal clusters, anti-Covid-19 ability of 2-deoxy-D-glucose: DFT calculations, MD and docking simulations

G Venkatesh, Y Sixto-López, P Vennila, YS Mary… - Journal of Molecular …, 2022 - Elsevier
Studies of the geometrical, vibration, absorption and physicochemical properties of 2-deoxy-
D-glucose with and without metal clusters are reported using the DFT method. 2-Deoxy-D …

[HTML][HTML] New insights into GluT1 mechanics during glucose transfer

T Galochkina, M Ng Fuk Chong, L Challali, S Abbar… - Scientific reports, 2019 - nature.com
Glucose plays a crucial role in the mammalian cell metabolism. In the erythrocytes and
endothelial cells of the blood-brain barrier, glucose uptake is mediated by the glucose …

[HTML][HTML] An appraisal of the current status of inhibition of glucose transporters as an emerging antineoplastic approach: Promising potential of new pan-GLUT …

MK Temre, A Kumar, SM Singh - Frontiers in Pharmacology, 2022 - frontiersin.org
Neoplastic cells displayed altered metabolism with accelerated glycolysis. Therefore, these
cells need a mammoth supply of glucose for which they display an upregulated expression …

Cellular binding and uptake of fluorescent glucose analogs 2-NBDG and 6-NBDG occurs independent of membrane glucose transporters

KE Hamilton, MF Bouwer, LL Louters, BD Looyenga - Biochimie, 2021 - Elsevier
The classical methods for determining glucose uptake rates in living cells involve the use of
isotopically labeled 2-deoxy-d-glucose or 3-O-methyl-d-glucose, which enter cells via well …

Chemical biology probes of mammalian GLUT structure and function

GD Holman - Biochemical Journal, 2018 - portlandpress.com
The structure and function of glucose transporters of the mammalian GLUT family of proteins
has been studied over many decades, and the proteins have fascinated numerous research …

GLUT1 biological function and inhibition: research advances

S Cao, Y Chen, Y Ren, Y Feng… - Future Medicinal Chemistry, 2021 - Taylor & Francis
The GLUT is a key regulator of glucose metabolism and is widely expressed on the surface
of most cells of the body. GLUT provides a variety of nutrients for the growth, proliferation …

[HTML][HTML] Red wine and green tea flavonoids are cis-allosteric activators and competitive inhibitors of glucose transporter 1 (GLUT1)-mediated sugar uptake

OA Ojelabi, KP Lloyd, JK De Zutter… - Journal of Biological …, 2018 - ASBMB
The antioxidant-and flavonoid-rich contents of red wine and green tea are reported to offer
protection against cancer, cardiovascular disease, and diabetes. Some studies, however …

Transporter oligomerisation: roles in structure and function

C Cecchetti, E Pyle, B Byrne - Biochemical Society Transactions, 2019 - portlandpress.com
Oligomerisation is a key feature of integral membrane transporters with roles in structure,
function and stability. In this review, we cover some very recent advances in our …