Refractive errors (myopia, hyperopia, and astigmatism) are complex heterogeneous
disorders of the human eye and are ideal for genetic investigation. Moderate to severe …

The ocular surface, which forms the interface between the eye and the external environment,
includes the cornea, corneoscleral limbus, the conjunctiva and the accessory glands that …

Central corneal thickness (CCT) is a highly heritable trait associated with complex eye
diseases such as keratoconus and glaucoma. We perform a genome-wide association meta …

A number of human diseases have been shown to be associated with mutation in the genes
encoding leucine-rich-repeat (LRR)-containing proteins. They include 16 different LRR …

High hyperopia is a common and severe form of refractive error. Genetic factors play
important roles in the development of high hyperopia but the exact gene responsible for this …

Small leucine rich repeat proteoglycans (SLRPs) are a group of active components of the
extracellular matrix in all tissues. SLRPs bind to collagens and regulate collagen fibril …

Posterior amorphous corneal dystrophy (PACD) is a rare, autosomal dominant disorder
affecting the cornea and iris. Next-generation sequencing of the previously identified PACD …

Purpose We developed human cornea organoids (HCOs) from induced pluripotent stem
cells (iPSCs) where single-cell RNA-sequence (scRNA-seq) analysis suggested similarity …

Background The small leucine-rich repeat proteins and proteoglycans (SLRPs) form an
important family of regulatory molecules that participate in many essential functions. They …

Purpose.: The purpose of this study was the morphologic and genetic characterization of the
novel eye size mutant Aca23 in the mouse. Methods.: The eyes of the mutants were …