Computational screening of medicinal plant phytochemicals to discover potent pan-serotype inhibitors against dengue virus

M Tahir ul Qamar, A Maryam, I Muneer, F Xing… - Scientific reports, 2019 - nature.com
Emergence of Dengue as one of the deadliest viral diseases prompts the need for
development of effective therapeutic agents. Dengue virus (DV) exists in four different …

Genome Investigations of Vector Competence in Aedes aegypti to Inform Novel Arbovirus Disease Control Approaches

DW Severson, SK Behura - Insects, 2016 - mdpi.com
Dengue (DENV), yellow fever, chikungunya, and Zika virus transmission to humans by a
mosquito host is confounded by both intrinsic and extrinsic variables. Besides virulence …

Flavivirus infection uncouples translation suppression from cellular stress responses

H Roth, V Magg, F Uch, P Mutz, P Klein, K Haneke… - MBio, 2017 - Am Soc Microbiol
As obligate parasites, viruses strictly depend on host cell translation for the production of
new progeny, yet infected cells also synthesize antiviral proteins to limit virus infection …

Analysis of synonymous codon usage bias of Zika virus and its adaption to the hosts

H Wang, S Liu, B Zhang, W Wei - PLoS One, 2016 - journals.plos.org
Zika virus (ZIKV) is a mosquito-borne virus (arbovirus) in the family Flaviviridae, and the
symptoms caused by ZIKV infection in humans include rash, fever, arthralgia, myalgia …

Nucleotide composition of the Zika virus RNA genome and its codon usage

F van Hemert, B Berkhout - Virology journal, 2016 - Springer
Background RNA viruses have genomes with a distinct nucleotide composition and codon
usage. We present the global characteristics of the RNA genome of Zika virus (ZIKV), an …

Analysis of genotype diversity and evolution of Dengue virus serotype 2 using complete genomes

VP Waman, P Kolekar, MR Ramtirthkar, MM Kale… - PeerJ, 2016 - peerj.com
Background Dengue is one of the most common arboviral diseases prevalent worldwide
and is caused by Dengue viruses (genus Flavivirus, family Flaviviridae). There are four …

Evolutionary and codon usage preference insights into spike glycoprotein of SARS-CoV-2

YS Malik, MI Ansari, JJ Kattoor, R Kaushik… - Briefings in …, 2021 - academic.oup.com
Interaction of SARS-CoV-2 spike glycoprotein with the ACE2 cell receptor is very crucial for
virus attachment to human cells. Selected mutations in SARS-CoV-2 S-protein are reported …

Impact of the biased nucleotide composition of viral RNA genomes on RNA structure and codon usage

F van Hemert, AC van der Kuyl… - Journal of General …, 2016 - microbiologyresearch.org
We are interested in the influence of nucleotide composition on the fundamental
characteristics of the virus RNA genome. Most RNA viruses have genomes with a distinct …

Analysis of codon usage bias of Crimean-Congo hemorrhagic fever virus and its adaptation to hosts

SU Rahman, X Yao, X Li, D Chen, S Tao - Infection, Genetics and Evolution, 2018 - Elsevier
Crimean-Congo hemorrhagic fever virus (CCHFV) is a negative-sense, single stranded RNA
virus with a three-segmented genome that belongs to the genus Nairovirus within the family …

Analysis of codon usage patterns and influencing factors in Nipah virus

S Chakraborty, B Deb, PA Barbhuiya, A Uddin - Virus research, 2019 - Elsevier
Codon usage bias (CUB) is the unequal usage of synonymous codons of an amino acid in
which some codons are used more often than others and is widely used in understanding …