Background Infants born extremely preterm (< 28 weeks gestational age (GA)) face a high
risk of neonatal mortality. Bronchopulmonary dysplasia (BPD) is the most common morbidity …

Preterm infants are at increased risk for patent ductus arteriosus (PDA). Prolonged exposure
to PDA may be deleterious and has been associated with neonatal morbidity and mortality …

300 increased to< 90%. 7, 8 More recently, the Canadian Neonatal Network evaluated the
definitions of BPD that were commonly used for epidemiology and clinical trial outcomes for …

The ductus arteriosus is likely to close without treatment in most infants born at gestational
age (GA)> 28 weeks (73%), and those with birth weight> 1000 g (94%). However, the rates …

A persistent left-to-right shunt through a patent ductus arteriosus (PDA) increases the rate of
hydrostatic fluid filtration into the lung's interstitium, impairs pulmonary mechanics, and …

Failure of ductus arteriosus closure after preterm birth is associated with significant
morbidities. Ductal closure requires and is regulated by a complex interplay of molecular …

Bronchopulmonary dysplasia (BPD) is the most common lung complication of prematurity.
Despite extensive research, our understanding of its pathophysiology remains limited, as …

Bronchopulmonary Dysplasia (BPD) is a multifactorial disease affecting over 35% of
extremely preterm infants born each year. Despite the advances made in understanding the …

Objective To examine the effects of early echocardiography-targeted ibuprofen treatment of
large patent ductus arteriosus (PDA) on survival without cerebral palsy at 24 months of …

The optimal management strategy for patent ductus arteriosus in preterm infants remains a
topic of debate. Available evidence for a treatment strategy might be biased by the delayed …