Angiogenesis inhibitors: current strategies and future prospects

KM Cook, WD Figg - CA: a cancer journal for clinicians, 2010 - Wiley Online Library
Angiogenesis has become an attractive target for drug therapy because of its key role in
tumor growth. An extensive array of compounds is currently in preclinical development, with …

[HTML][HTML] Angiogenesis and vascular functions in modulation of obesity, adipose metabolism, and insulin sensitivity

Y Cao - Cell metabolism, 2013 - cell.com
White and brown adipose tissues are hypervascularized and the adipose vasculature
displays phenotypic and functional plasticity to coordinate with metabolic demands of …

Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470

R Satchi-Fainaro, M Puder, JW Davies, HT Tran… - Nature medicine, 2004 - nature.com
Angiogenesis is crucial for tumor growth. Angiogenesis inhibitors, such as O-(chloracetyl-
carbamoyl) fumagillol (TNP-470), are thus emerging as a new class of anticancer drugs. In …

Cervical cancer–State of the science: From angiogenesis blockade to checkpoint inhibition

LE Minion, KS Tewari - Gynecologic oncology, 2018 - Elsevier
Vascular endothelial growth factor (VEGF) has emerged as a therapeutic target in several
malignancies, including cervical cancer. Chemotherapy doublets combined with the fully …

An orally delivered small-molecule formulation with antiangiogenic and anticancer activity

O Benny, O Fainaru, A Adini, F Cassiola… - Nature …, 2008 - nature.com
Targeting angiogenesis, the formation of blood vessels, is an important modality for cancer
therapy. TNP-470, a fumagillin analog, is among the most potent and broad-spectrum …

3, 3′-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice

X Chang, JC Tou, C Hong, HA Kim, JE Riby… - …, 2005 - academic.oup.com
Studies have linked the consumption of broccoli and other cruciferous vegetables to a
reduced risk of breast cancer. The phytochemical indole-3-carbinol (I3C), present in …

Anti‐angiogenic drugs: from bench to clinical trials

AR Quesada, R Muñoz‐Chápuli… - Medicinal research …, 2006 - Wiley Online Library
Angiogenesis, the generation of new capillaries through a process of pre‐existing
microvessel sprouting, is under stringent control and normally occurs only during embryonic …

TNP-470: an angiogenesis inhibitor in clinical development for cancer

EA Kruger, WD Figg - Expert opinion on investigational drugs, 2000 - Taylor & Francis
TNP-470, an analogue of fumagillin, has been shown to inhibit angiogenesis in vitro and in
vivo. In 1992, TNP-470 entered clinical development for cancer as an anti-angiogenic agent …

Imaging of integrins as biomarkers for tumor angiogenesis

W Cai, G Niu, X Chen - Current pharmaceutical design, 2008 - ingentaconnect.com
The integrin family plays important roles during tumor angiogenesis, the formation of new
blood vessels from pre-existing vasculature. Traditional structural and functional imaging …

Angiogenesis and cancer control: from concept to therapeutic trial

S Brem - Cancer Control, 1999 - journals.sagepub.com
Background There is extraordinary interest in developing angiosuppressive agents for
cancer treatment. Several new agents appear promising for the treatment of a variety of …