White and brown adipose tissues are hypervascularized and the adipose vasculature displays phenotypic and functional plasticity to coordinate with metabolic demands of …
R Satchi-Fainaro, M Puder, JW Davies, HT Tran… - Nature medicine, 2004 - nature.com
Angiogenesis is crucial for tumor growth. Angiogenesis inhibitors, such as O-(chloracetyl- carbamoyl) fumagillol (TNP-470), are thus emerging as a new class of anticancer drugs. In …
LE Minion, KS Tewari - Gynecologic oncology, 2018 - Elsevier
Vascular endothelial growth factor (VEGF) has emerged as a therapeutic target in several malignancies, including cervical cancer. Chemotherapy doublets combined with the fully …
O Benny, O Fainaru, A Adini, F Cassiola… - Nature …, 2008 - nature.com
Targeting angiogenesis, the formation of blood vessels, is an important modality for cancer therapy. TNP-470, a fumagillin analog, is among the most potent and broad-spectrum …
X Chang, JC Tou, C Hong, HA Kim, JE Riby… - …, 2005 - academic.oup.com
Studies have linked the consumption of broccoli and other cruciferous vegetables to a reduced risk of breast cancer. The phytochemical indole-3-carbinol (I3C), present in …
AR Quesada, R Muñoz‐Chápuli… - Medicinal research …, 2006 - Wiley Online Library
Angiogenesis, the generation of new capillaries through a process of pre‐existing microvessel sprouting, is under stringent control and normally occurs only during embryonic …
EA Kruger, WD Figg - Expert opinion on investigational drugs, 2000 - Taylor & Francis
TNP-470, an analogue of fumagillin, has been shown to inhibit angiogenesis in vitro and in vivo. In 1992, TNP-470 entered clinical development for cancer as an anti-angiogenic agent …
W Cai, G Niu, X Chen - Current pharmaceutical design, 2008 - ingentaconnect.com
The integrin family plays important roles during tumor angiogenesis, the formation of new blood vessels from pre-existing vasculature. Traditional structural and functional imaging …
S Brem - Cancer Control, 1999 - journals.sagepub.com
Background There is extraordinary interest in developing angiosuppressive agents for cancer treatment. Several new agents appear promising for the treatment of a variety of …