Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

Cell behaviour is strongly influenced by physical, mechanical contacts between cells and
their extracellular matrix. We review how the transcriptional regulators YAP and TAZ …

Eradicating tumor dormancy that develops following epidermal growth factor receptor
(EGFR) tyrosine kinase inhibitor (TKI) treatment of EGFR-mutant non-small cell lung cancer …

A growing body of evidence suggests that mechanical signals emanating from the cell's
microenvironment are fundamental regulators of cell behaviour. Moreover, at the …

Few cell signals match the impact of the transforming growth factor-β (TGFβ) family in
metazoan biology. TGFβ cytokines regulate cell fate decisions during development, tissue …

Cancer heterogeneity impacts therapeutic response, driving efforts to discover over-arching
rules that supersede variability. Here, we define pan-cancer binary classes based on distinct …

Hippo pathway components are structurally and functionally conserved and are notable for
their role in controlling organ size. More diverse functions of the Hippo pathway have been …

Cytokines of the transforming growth factor β (TGF-β) family, including TGF-βs, bone
morphogenic proteins (BMPs), activins, and Nodal, play crucial roles in embryonic …

Abstract The Hippo–YAP (Yes-associated protein) pathway is an evolutionarily and
functionally conserved regulator of organ size and growth with crucial roles in cell …

Background and Aims Cholestatic liver disease is characterized by gut dysbiosis and
excessive toxic hepatic bile acids (BAs). Modification of gut microbiota and repression of BA …