Human cytomegalovirus (HCMV) is a beta herpesvirus that establishes a life-long
persistence in the host, like all herpesviruses, by way of a latent infection. During latency …

Herpes simplex virus (HSV) establishes a latent infection in peripheral neurons and can
periodically reactivate to cause disease. Reactivation can be triggered by a variety of stimuli …

Mitochondria are dynamic organelles vital for energy production with now appreciated roles
in immune defense. During microbial infection, mitochondria serve as signaling hubs to …

During the morphogenesis of hepatitis B virus (HBV), an enveloped virus, two types of
virions are secreted:(i) a minor population of complete virions containing a mature …

Pseudorabies virus (PRV) is an alphaherpesvirus that infects the peripheral nervous system
(PNS). The natural host of PRV is the swine, but it can infect most mammals, including cattle …

Flaviviruses are arthropod-borne RNA viruses found worldwide that, when introduced into
the human body, cause diseases, including neuroinfections, that can lead to serious …

Herpes simplex virus-1 (HSV-1) establishes a latent infection in neurons and periodically
reactivates to cause disease. The stimuli that trigger HSV-1 reactivation have not been fully …

Neuroinvasive viruses, such as alpha herpesviruses (αHV) and rabies virus (RABV), initially
infect peripheral tissues, followed by invasion of the innervating axon termini. Virus particles …

Alpha herpesviruses naturally infect the peripheral nervous system, and can spread to the
central nervous system, causing severe debilitating or deadly disease. Because alpha …

Alphaherpesviruses, including herpes simplex virus type 1 (HSV-1), herpes simplex virus
type 2 (HSV-2), and varicella-zoster virus (VZV), infect a diverse array of hosts, spanning …