Human SMILE-derived stromal lenticule scaffold for regenerative therapy: Review and perspectives

M Santra, YC Liu, V Jhanji, GHF Yam - International Journal of Molecular …, 2022 - mdpi.com
A transparent cornea is paramount for vision. Corneal opacity is one of the leading causes of
blindness. Although conventional corneal transplantation has been successful in recovering …

Keratocyte biology

GHF Yam, AK Riau, ML Funderburgh, JS Mehta… - Experimental eye …, 2020 - Elsevier
The study of corneal stromal keratocytes is motivated by its strong association with corneal
health and visual function. They play a dominant role in the maintenance of corneal …

Pathogenesis of alkali injury-induced limbal stem cell deficiency: a literature survey of animal models

L Sprogyte, M Park, N Di Girolamo - Cells, 2023 - mdpi.com
Limbal stem cell deficiency (LSCD) is a debilitating ocular surface disease that eventuates
from a depleted or dysfunctional limbal epithelial stem cell (LESC) pool, resulting in corneal …

Sleep deprivation induces dry eye through inhibition of PPARα expression in corneal epithelium

L Tang, X Wang, J Wu, Z Zhang, S Wu… - … & Visual Science, 2018 - iovs.arvojournals.org
Purpose: To determine if sleep deprivation induces dry eye through altering peroxisome
proliferator-activated receptor alpha (PPARα) expression in mice. Methods: The “stick over …

Leucine-rich α-2-glycoprotein-1 promotes diabetic corneal epithelial wound healing and nerve regeneration via regulation of matrix metalloproteinases

W Li, X Wang, J Cheng, J Li, Q Wang, Q Zhou… - Experimental Eye …, 2020 - Elsevier
Abstract Leucine-rich α-2-glycoprotein-1 (LRG1) is involved in several pathophysiological
processes, including angiogenesis, cutaneous wound repair and cancer metastasis. In this …

Potential therapeutic effects of peroxisome proliferator-activated receptors on corneal diseases

BJ Chow, IXY Lee, C Liu, YC Liu - Experimental Biology and …, 2024 - pmc.ncbi.nlm.nih.gov
The cornea is an avascular tissue in the eye that has multiple functions in the eye to
maintain clear vision which can significantly impair one's vision when subjected to damage …

Human Umbilical Cord Mesenchymal Stromal Cell-Derived Extracellular Vesicles Induce Fetal Wound Healing Features Revealed by Single-Cell RNA Sequencing

Y Liu, M Zhang, C Wang, H Chen, D Su, C Yang… - ACS …, 2024 - ACS Publications
The potential of human umbilical cord mesenchymal stromal cell-derived extracellular
vesicles (hucMSC-EVs) in wound healing is promising, yet a comprehensive understanding …

Fenofibrate suppresses corneal neovascularization by regulating lipid metabolism through PPARα signaling pathway

T Zhou, K Yan, Y Zhang, L Zhu, Y Liao… - Frontiers in …, 2022 - frontiersin.org
Purpose: The purpose of this study was to explore the potential underlying mechanism of
anti-vascular effects of peroxisome proliferator–activated receptor α (PPARα) agonist …

Assessment of therapeutic options for reducing alkali burn-induced corneal neovascularization and inflammation

A Bakunowicz-Łazarczyk, B Urban - Advances in Medical Sciences, 2016 - Elsevier
This article aims to review and provide the current knowledge of the possibilities of topical
treatment of corneal neovascularization due to alkali burns, evidenced by laboratory …

[HTML][HTML] Shark Cartilage-Derived Anti-Angiogenic Peptide Inhibits Corneal Neovascularization

Y Li, A Chen, A Hong, S Xiong, X Chen, Q Xie - Bioengineering, 2024 - mdpi.com
Corneal neovascularization is a significant cause of vision loss, often resulting in corneal
clouding and chronic inflammation. Shark cartilage is widely recognized as a significant …