This review is dedicated to E-cadherin, a calcium-dependent cell-cell adhesion molecule
with pivotal roles in epithelial cell behavior, tissue formation, and suppression of cancer. As …

There are many misconceptions surrounding the roles of protein phosphatases in the
regulation of signal transduction, perhaps the most damaging of which is the erroneous view …

Although vascular endothelial growth factor (VEGF) induces angiogenesis, it also disrupts
vascular barrier function in diseased tissues. Accordingly, VEGF expression in cancer and …

This review addresses the cellular and molecular mechanisms of cadherin-based tissue
morphogenesis. Tissue physiology is profoundly influenced by the distinctive organizations …

Cell migration is a process which is essential during embryonic development, throughout
adult life and in some pathological conditions. Cadherins, and more specifically the neural …

The formation of stable cell–cell adhesions by type I cadherins depends on the association
of their cytoplasmic domain with β-catenin, and of β-catenin with α-catenin. The binding of β …

Pleiotrophin (PTN) is a platelet-derived growth factor-inducible, 18-kDa heparin-binding
cytokine that signals diverse phenotypes in normal and deregulated cellular growth and …

In human epidermis, functional symbiosis requires homeostatic balance between
keratinocytes and melanocytes. Compelling evidence from co-culture studies demonstrated …

VE‐cadherin is the essential adhesion molecule in endothelial adherens junctions, and the
regulation of protein tyrosine phosphorylation is thought to be important for the control of …

Cadherins are single pass transmembrane proteins that mediate Ca 2+-dependent
homophilic cell-cell adhesion by linking the cytoskeletons of adjacent cells. In adherens …