Ketamine was introduced into clinical practice in the 1960s and continues to be both
clinically useful and scientifically fascinating. With considerably diverse molecular targets …

The obsessive–compulsive spectrum refers to disorders drawn from several diagnostic
categories that share core features related to obsessive–compulsive disorder (OCD), such …

There has been little analysis of neurochemical correlates of compulsive behaviour to
illuminate its underlying neural mechanisms. We use 7-Tesla proton magnetic resonance …

Importance Obsessive-compulsive disorder (OCD) is a common and often debilitating
psychiatric illness. Recent advances in the understanding of the neuroscience of OCD have …

Compulsive behaviour, an apparently irrational perseveration in often maladaptive acts, is a
potential transdiagnostic symptom of several neuropsychiatric disorders, including …

Introduction Converging evidence suggests that ketamine elicits antidepressant effects via
enhanced neuroplasticity precipitated by a surge of glutamate and modulation of GABA …

Intrusive memories are a common feature of many psychopathologies, and suppression-
induced forgetting of unwanted memories appears as a critical ability to preserve mental …

Abnormalities in brain γ‐aminobutyric acid (GABA) have been implicated in various
neuropsychiatric and neurological disorders. However, in vivo GABA detection by 1H MRS …

Methods This systematic review aims to investigate the effects of ketamine in OCD, following
the Preferred Reporting Items for Systematic Review and Meta-analyses Protocols (PRISMA …

Abstract Obsessive-Compulsive Disorder (OCD), characterized by intrusive thoughts
(obsessions) and repetitive behaviors (compulsions), is associated with dysfunction in fronto …