Upon DNA damage or other stressors, the tumor suppressor p53 is activated, leading to
transient expression of the cyclin-dependent kinase inhibitor (CKI) p21. This either triggers …

p21Waf/CIP1 is a small unstructured protein that binds and inactivates cyclin-dependent
kinases (CDKs). To this end, p21 levels increase following the activation of the p53 tumor …

Accurate replication of DNA requires stringent regulation to ensure genome integrity. In
human cells, thousands of origins of replication are coordinately activated during S phase …

Following DNA damage caused by exogenous sources, such as ionizing radiation, the
tumour suppressor p53 mediates cell cycle arrest via expression of the CDK inhibitor, p21 …

The p21CDKN1A protein is an important player in the maintenance of genome stability
through its function as a cyclin-dependent kinase inhibitor, leading to cell-cycle arrest after …

The deubiquitinase USP1 is a critical regulator of genome integrity through the
deubiquitylation of Fanconi Anemia proteins and the DNA replication processivity factor …

Cellular feedback systems ensure genome maintenance during DNA replication. When
replication forks stall, newly replicated DNA is protected by pathways that limit excessive …

Recent studies have described a DNA damage tolerance pathway choice that involves a
competition between PrimPol-mediated repriming and fork reversal. Screening different …

Traditionally, the p21 protein has been viewed as limiting cancer progression and promoting
aging. In contrast, there are reports that p21 can enhance cancer survival and limit tissue …

DNA replication stress is often defined by the slowing or stalling of replication fork
progression leading to local or global DNA synthesis inhibition. Failure to resolve replication …