Inflammation context in Alzheimer's disease, a relationship intricate to define

C Novoa, P Salazar, P Cisternas, C Gherardelli… - Biological Research, 2022 - Springer
Abstract Alzheimer's disease (AD), the most common form of dementia, is characterized by
the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates …

Mechanisms of blood–brain barrier dysfunction in traumatic brain injury

A Cash, MH Theus - International journal of molecular sciences, 2020 - mdpi.com
Traumatic brain injuries (TBIs) account for the majority of injury-related deaths in the United
States with roughly two million TBIs occurring annually. Due to the spectrum of severity and …

Traumatic epidural and subdural hematoma: epidemiology, outcome, and dating

M Aromatario, A Torsello, S D'Errico, G Bertozzi… - Medicina, 2021 - mdpi.com
Epidural hematomas (EDHs) and subdural hematomas (SDHs), or so-called extra-axial
bleedings, are common clinical entities after a traumatic brain injury (TBI). A forensic …

A tilted axis: maladaptive inflammation and HPA axis dysfunction contribute to consequences of TBI

ZM Tapp, JP Godbout, ON Kokiko-Cochran - Frontiers in neurology, 2019 - frontiersin.org
Each year approximately 1.7 million people sustain a traumatic brain injury (TBI) in the US
alone. Associated with these head injuries is a high prevalence of neuropsychiatric …

Glymphatic system a window on TBI pathophysiology: a systematic review

M Ferrara, G Bertozzi, G Volonnino, N Di Fazio… - International Journal of …, 2022 - mdpi.com
Background: In recent years, the attention of the scientific world has focused on a clearance
system of brain waste metabolites, called the glymphatic system, based on its similarity to …

Mechanisms of transmission and processing of pain: A narrative review

G Di Maio, I Villano, CR Ilardi, A Messina… - International Journal of …, 2023 - mdpi.com
Knowledge about the mechanisms of transmission and the processing of nociceptive
information, both in healthy and pathological states, has greatly expanded in recent years …

Sudden death in adults: a practical flow chart for pathologist guidance

F Sessa, M Esposito, G Messina, G Di Mizio… - Healthcare, 2021 - mdpi.com
The medico-legal term “sudden death (SD)” refers to those deaths that are not preceded by
significant symptoms. SD in apparently healthy individuals (newborn through to adults) …

The Expression of FOXO3a as a Forensic Diagnostic Tool in Cases of Traumatic Brain Injury: An Immunohistochemical Study

A Maiese, F Spina, G Visi, F Del Duca… - International Journal of …, 2023 - mdpi.com
Traumatic brain injury (TBI) is one of the most well-known causes of neurological impairment
and disability in the world. The Forkhead Box class O (FOXO) 3a is a transcription factor that …

YTHDF1 attenuates TBI-induced brain-gut axis dysfunction in mice

P Huang, M Liu, J Zhang, X Zhong… - International Journal of …, 2023 - mdpi.com
The brain-gut axis (BGA) is a significant bidirectional communication pathway between the
brain and gut. Traumatic brain injury (TBI) induced neurotoxicity and neuroinflammation can …

Diffuse axonal injury: clinical prognostic factors, molecular experimental models and the impact of the trauma related oxidative stress. An extensive review concerning …

M Palmieri, A Frati, A Santoro, P Frati… - International Journal of …, 2021 - mdpi.com
Traumatic brain injury (TBI) is a condition burdened by an extremely high rate of morbidity
and mortality and can result in an overall disability rate as high as 50% in affected …