Autophagy and Alzheimer's disease

Q Li, Y Liu, M Sun - Cellular and molecular neurobiology, 2017 - Springer
Autophagy is an essential degradation pathway in clearing abnormal protein aggregates in
mammalian cells and is responsible for protein homeostasis and neuronal health. Several …

Focusing on formononetin: recent perspectives for its neuroprotective potentials

J Tian, XQ Wang, Z Tian - Frontiers in Pharmacology, 2022 - frontiersin.org
Nervous system is the most complex system of the human body, hence, the neurological
diseases often lack effective treatment strategies. Natural products have the potential to yield …

Scleral hypoxia is a target for myopia control

H Wu, W Chen, F Zhao, Q Zhou… - Proceedings of the …, 2018 - National Acad Sciences
Worldwide, myopia is the leading cause of visual impairment. It results from inappropriate
extension of the ocular axis and concomitant declines in scleral strength and thickness …

Novel disease-modifying therapies for Alzheimer's disease

T Jiang, JT Yu, L Tan - Journal of Alzheimer's disease, 2012 - content.iospress.com
Alzheimer's disease (AD) is the most common progressive dementia in the elderly and
places an enormous burden on the individual and society. Presently, the treatments for AD …

Pathogenesis and prevention of worsening axial elongation in pathological myopia

S Pugazhendhi, B Ambati, AA Hunter - Clinical ophthalmology, 2020 - Taylor & Francis
Purpose This review discusses the etiology and pathogenesis of myopia, prevention of
disease progression and worsening axial elongation, and emerging myopia treatment …

Neuroprotective potential of formononetin, a naturally occurring isoflavone phytoestrogen

L Singh, H Kaur, G Chandra Arya… - Chemical Biology & …, 2024 - Wiley Online Library
The increased prevalence of neurological illnesses is a burgeoning challenge to the public
healthcare system and presents greater financial pressure. Formononetin, an O‐methylated …

Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies

L Toigo, EI dos Santos Teodoro, AC Guidi… - DARU Journal of …, 2023 - Springer
Objectives This scoping review aims to present flavonoid compounds' promising effects and
possible mechanisms of action on potential therapeutic targets in the SARS-CoV-2 infection …

Cartilage-targeting poly (ethylene glycol)(PEG)-formononetin (FMN) nanodrug for the treatment of osteoarthritis

W Xiong, Q Lan, X Liang, J Zhao, H Huang… - Journal of …, 2021 - Springer
Intra-articular (IA) injection is an efficient treatment for osteoarthritis, which will minimize
systemic side effects. However, the joint experiences rapid clearance of therapeutics after …

Formononetin attenuates IL-1β-induced apoptosis and NF-κB activation in INS-1 cells

Y Wang, Y Zhu, L Gao, H Yin, Z Xie, D Wang, Z Zhu… - Molecules, 2012 - mdpi.com
Several studies suggest that the inflammation plays a role in the pathogenesis of some
glucose disorders in adults. Exposure of pancreatic β-cells to cytokines, such as interleukin …

Hypobaric hypoxia triggers pyroptosis in the retina via NLRP3 inflammasome activation

X Xin, K Yang, H Liu, Y Li - Apoptosis, 2022 - Springer
Hypobaric hypoxia initiates multiple impairment to the retina and is the major cause
contributing to retinal function deficits such as high altitude retinopathy. However, the …