Adaptive immunity, orchestrated by B-cells and T-cells, plays a crucial role in protecting the
body from pathogenic invaders and can be used as tools to enhance the body's defense …

Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain
tumor in adults. Current treatment options typically consist of surgery followed by …

Chimeric antigen receptor T cells (CAR T cells) are engineered cells expressing a chimeric
antigen receptor (CAR) against a specific tumor antigen (TA) that allows for the identification …

Simple Summary Glioblastoma (GBM) is the most severe and aggressive form of primary
brain tumor with a poor prognosis. Currently, the treatment for GBM treatment involves …

Background Glioblastoma (GBM) is recognized as among the most aggressive forms of
brain tumor. Patients typically present with a five-year survival rate of less than 6% with …

Extracellular vesicles (EV) are vesicular vesicles with phospholipid bilayer, which are
present in biological fluids and extracellular microenvironment. Extracellular vesicles serve …

High grade gliomas are identified as malignant central nervous tumors that spread rapidly
and have a universally poor prognosis. Historically high grade gliomas in the pediatric …

Background Compared with open gastrectomy (OG), laparoscopic gastrectomy (LG) for
gastric cancer has achieved rapid development and popularities in the past decades …

Purpose Radio-resistance is recognized as a main factor in the failure of radiotherapy in
oesophageal squamous cell carcinoma (ESCC). Aberrant cell surface glycosylation has …

Abstract Treatment for malignant primary brain tumors, including glioblastoma, remains a
significant challenge despite advances in therapy. CAR-T cell immunotherapy represents a …