Cells modulate their activities in response to signals from their surrounding environment.
Single cell organisms respond mainly to nutrient cues, many of which are able to cross the …

Insulin plays a key role in regulating a wide range of cellular processes. However, until
recently little was known about the signalling pathways that are involved in linking the …

Phosphoinositide kinases (PI3Ks) play an important role in mitogenic signaling and cell
survival, cytoskeletal remodeling, metabolic control and vesicular trafficking. Here we …

We have reported previously that Ras interacts with the catalytic subunit of phosphoinositide
3‐kinase (PI 3‐kinase) in a GTP‐dependent manner. The affinity of the interaction of Ras …

Ligand binding to cell surface receptors initiates a cascade of signaling events regulated by
dynamic phosphorylation events on a multitude of pathway proteins. Quantitative features …

Phosphatidylinositol 3‐kinase (PI 3‐kinase) has a regulatory 85 kDa adaptor subunit whose
SH2 domains bind phosphotyrosine in specific recognition motifs, and a catalytic 110 kDa …

We examined the role of 185-kDa insulin receptor substrate-1 (IRS-1) and
phosphatidylinositol 3-kinase (PI3-kinase) in the signaling pathway of insulin-stimulated …

Phosphatidylinositol 3-kinase (PI-3 kinase) is implicated in the regulation of diverse cellular
processes, including insulin-stimulated glucose transport. PI-3 kinase is composed of a 110 …

The phosphatidylinositol 3-kinase (PI3K) pathway is a critical regulator of many cellular
processes including cell survival, growth, proliferation and motility. Not surprisingly …

The effects of wortmannin (WT), an inhibitor of phosphatidylinositol (PI) 3-kinase, on
differentiation of PC12 cells were analyzed. WT inhibited PI 3-kinase activity of PC12 cells at …