Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

Cyclic adenosine monophosphate (cAMP) is the first discovered second messenger, which
plays pivotal roles in cell signaling, and regulates many physiological and pathological …

The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

Pseudouridine is the most frequent epitranscriptomic modification. However, its cellular
functions remain largely unknown. Here, we show that pseudouridine synthase 7 (PUS7) is …

Hutchinson-Gilford progeria syndrome (HGPS) is a rare, invariably fatal premature aging
disorder. The disease is caused by constitutive production of progerin, a mutant form of the …

Cancer stem cells (CSCs), known also as tumor-initiating cells, are quiescent, pluripotent,
self-renewing neoplastic cells that were first identified in hematologic tumors and soon after …

Tissue development and homeostasis are governed by the actions of stem cells. Multipotent
cells are capable of self-renewal during the course of one's lifetime. The accurate and …

Stem cell aging and exhaustion are considered important drivers of organismal aging. Age-
associated declines in stem cell function are characterized by metabolic and epigenetic …

PTEN is one of the most frequently inactivated tumor suppressor genes in cancer. Loss or
variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human …