Towards a molecular understanding of microRNA-mediated gene silencing

S Jonas, E Izaurralde - Nature reviews genetics, 2015 - nature.com
MicroRNAs (miRNAs) are a conserved class of small non-coding RNAs that assemble with
Argonaute proteins into miRNA-induced silencing complexes (miRISCs) to direct post …

The functions of microRNAs: mRNA decay and translational repression

H Iwakawa, Y Tomari - Trends in cell biology, 2015 - cell.com
MicroRNAs (miRNAs) are a class of endogenous small noncoding RNAs, which regulate
complementary mRNAs by inducing translational repression and mRNA decay. Although …

mRNA destabilization is the dominant effect of mammalian microRNAs by the time substantial repression ensues

SW Eichhorn, H Guo, SE McGeary, RA Rodriguez-Mias… - Molecular cell, 2014 - cell.com
MicroRNAs (miRNAs) regulate target mRNAs through a combination of translational
repression and mRNA destabilization, with mRNA destabilization dominating at steady state …

MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship

AE Pasquinelli - Nature Reviews Genetics, 2012 - nature.com
MicroRNAs (miRNAs) have emerged as key gene regulators in diverse biological pathways.
These small non-coding RNAs bind to target sequences in mRNAs, typically resulting in …

Analysis of 13 cell types reveals evidence for the expression of numerous novel primate-and tissue-specific microRNAs

E Londin, P Loher, AG Telonis… - Proceedings of the …, 2015 - National Acad Sciences
Two decades after the discovery of the first animal microRNA (miRNA), the number of
miRNAs in animal genomes remains a vexing question. Here, we report findings from …

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

E Huntzinger, E Izaurralde - Nature Reviews Genetics, 2011 - nature.com
Despite their widespread roles as regulators of gene expression, important questions
remain about target regulation by microRNAs. Animal microRNAs were originally thought to …

Mammalian microRNAs predominantly act to decrease target mRNA levels

H Guo, NT Ingolia, JS Weissman, DP Bartel - Nature, 2010 - nature.com
MicroRNAs (miRNAs) are endogenous∼ 22-nucleotide RNAs that mediate important gene-
regulatory events by pairing to the mRNAs of protein-coding genes to direct their repression …

Regulation of mRNA translation and stability by microRNAs

MR Fabian, N Sonenberg… - Annual review of …, 2010 - annualreviews.org
MicroRNAs (miRNAs) are small noncoding RNAs that extensively regulate gene expression
in animals, plants, and protozoa. miRNAs function posttranscriptionally by usually base …

[HTML][HTML] MicroRNAs: processing, maturation, target recognition and regulatory functions

GC Shukla, J Singh, S Barik - Molecular and cellular pharmacology, 2011 - ncbi.nlm.nih.gov
The remarkable discovery of small noncoding microRNAs (miRNAs) and their role in
posttranscriptional gene regulation have revealed another fine-tuning step in the expression …

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

W Filipowicz, SN Bhattacharyya… - Nature reviews …, 2008 - nature.com
MicroRNAs constitute a large family of small, approximately 21-nucleotide-long, non-coding
RNAs that have emerged as key post-transcriptional regulators of gene expression in …