Deuterated drugs and biomarkers in the COVID-19 pandemic

RD Jansen-van Vuuren, L Jedlovčnik, J Košmrlj… - ACS …, 2022 - ACS Publications
Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Initially identified in Wuhan …

The role of cytochrome P450 enzymes in COVID-19 pathogenesis and therapy

G Wang, B Xiao, J Deng, L Gong, Y Li, J Li… - Frontiers in …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19) has become a new public health crisis threatening
the world. Dysregulated immune responses are the most striking pathophysiological …

MS-based targeted profiling of oxylipins in COVID-19: A new insight into inflammation regulation

D Biagini, M Franzini, P Oliveri, T Lomonaco… - Free Radical Biology …, 2022 - Elsevier
The key role of inflammation in COVID-19 induced many authors to study the cytokine storm,
whereas the role of other inflammatory mediators such as oxylipins is still poorly understood …

[HTML][HTML] Pro-resolving metabolites: Future of the fish oil supplements

A Maliha, M Tahsin, TZ Fabia, SM Rahman… - Journal of Functional …, 2024 - Elsevier
Specialized pro-resolving mediators (SPMs) derived from omega-3 fatty acids have
emerged as promising therapeutic agents for managing inflammatory diseases. This …

Plasma oxylipins and their precursors are strongly associated with COVID-19 severity and with immune response markers

N Karu, A Kindt, L Lamont, AJ van Gammeren… - Metabolites, 2022 - mdpi.com
COVID-19 is characterised by a dysregulated immune response, that involves signalling
lipids acting as mediators of the inflammatory process along the innate and adaptive …

Prostaglandins and non-steroidal anti-inflammatory drugs in Covid-19

HM Al-Kuraishy, AI Al-Gareeb… - Biotechnology and …, 2024 - Taylor & Francis
In response to different viral infections, including SARS-CoV-2 infection, pro-inflammatory,
anti-inflammatory cytokines, and bioactive lipids are released from infected and immune …

SARS-cov2 infection alters tryptophan catabolism and phospholipid metabolism

G Kaur, X Ji, I Rahman - Metabolites, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19) has so far infected hundreds of million individuals,
with several million deaths worldwide. The lack of understanding of the disease …

The effect of SARS-CoV-2 variants on the plasma oxylipins and PUFAs of COVID-19 patients

D Biagini, P Oliveri, A Baj, D Dalla Gasperina… - Prostaglandins & Other …, 2023 - Elsevier
Oxylipins are important signalling compounds that are significantly involved in the regulation
of the immune system and the resolution of inflammation. Lipid metabolism is strongly …

Activating endogenous resolution pathways by soluble epoxide hydrolase inhibitors for the management of COVID‐19

M Manickam, S Meenakshisundaram… - Archiv der …, 2022 - Wiley Online Library
Anti‐inflammatory, specialized proresolving mediators such as resolvins, protectins,
maresins, and lipoxins derived from polyunsaturated acids may play a potential role in lung …

Metabolomics-directed nanotechnology in viral diseases management: COVID-19 a case study

MO El-Derany, DMF Hanna, J Youshia… - Pharmacological …, 2023 - Springer
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently regarded
as the twenty-first century's plague accounting for coronavirus disease 2019 (COVID-19) …