Mammalian cell expression has become the dominant recombinant protein production
system for clinical applications because of its capacity for post-translational modification and …

The production of proteins in appropriate quantity and quality is an essential requirement of
the present time. There appears to be a progressive increase in the application of …

IL-15 is an important cytokine for the function of the immune system, but the form (s) of IL-15
produced in the human body are not fully characterized. Coexpression of the single-chain IL …

We show that co-expression of interleukin 15 (IL-15) and IL-15 receptor α (IL-15Rα) in the
same cell allows for the intracellular interaction of the two proteins early after translation …

Interleukin-15 (IL-15), a 114-amino acid cytokine related to IL-2, regulates immune
homeostasis and the fate of many lymphocyte subsets. We reported that, in the blood of mice …

IL-12 is a 70-kDa heterodimeric cytokine composed of the p35 and p40 subunits. To
maximize cytokine production from plasmid DNA, molecular steps controlling IL-12p70 …

DNA vaccines are a rapidly deployed next generation vaccination platform for treatment of
human and animal disease. DNA delivery devices, such as electroporation and needle free …

Dysregulations in the inflammatory response of the body to pathogens could progress
toward a hyperinflammatory condition amplified by positive feedback loops and associated …

We used optimized DNA expression vectors to compare two gene delivery methodologies in
rhesus macaques, namely direct DNA injection and in vivo adaptive constant-current …

Ideal immunogenicity in antigens is a prerequisite to eliciting a sufficiently strong immune
and memory response via either DNA or protein vaccines. To improve immunogenicity …