Biofabrication strategies and engineered in vitro systems for vascular mechanobiology
The vascular system is integral for maintaining organ‐specific functions and homeostasis.
Dysregulation in vascular architecture and function can lead to various chronic or acute …
Dysregulation in vascular architecture and function can lead to various chronic or acute …
Recurrent graph optimal transport for learning 3D flow motion in particle tracking
Flow visualization technologies such as particle tracking velocimetry are broadly used for
studying three-dimensional turbulent flow in natural and industrial processes. Despite the …
studying three-dimensional turbulent flow in natural and industrial processes. Despite the …
Recent advancements in in vitro models of traumatic brain injury
MKR Dwyer, B Morrison III - Current Opinion in Biomedical Engineering, 2022 - Elsevier
Traumatic brain injury (TBI) is a major cause of disability and death. However, despite
increased attention due to explosive detonations in warzones and discussions of the long …
increased attention due to explosive detonations in warzones and discussions of the long …
The White Matter Fiber Tract Deforms Most in the Perpendicular Direction During In Vivo Volunteer Impacts
White matter (WM) tract-related strains are increasingly used to quantify brain mechanical
responses, but their dynamics in live human brains during in vivo impact conditions remain …
responses, but their dynamics in live human brains during in vivo impact conditions remain …
Neural cell injury pathology due to high-rate mechanical loading
Successful detection and prevention of brain injuries relies on the quantitative identification
of cellular injury thresholds associated with the underlying pathology. Here, by combining a …
of cellular injury thresholds associated with the underlying pathology. Here, by combining a …
Toward a comprehensive delineation of white matter tract-related deformation
Finite element (FE) models of the human head are valuable instruments to explore the
mechanobiological pathway from external loading, localized brain response, and resultant …
mechanobiological pathway from external loading, localized brain response, and resultant …
Open Source, In-Situ, Intermediate Strain-Rate Tensile Impact Device for Soft Materials and Cell Culture Systems
L Summey, J Zhang, AK Landauer, J Sergay… - Experimental …, 2023 - Springer
Background Intermediate-strain-rate mechanical testing of soft and biological materials is
important when designing, measuring, predicting, or manipulating an object or system's …
important when designing, measuring, predicting, or manipulating an object or system's …
Application of mild hypothermia successfully mitigates neural injury in a 3D in-vitro model of traumatic brain injury
Therapeutic hypothermia (TH) is an attractive target for mild traumatic brain injury (mTBI)
treatment, yet significant gaps in our mechanistic understanding of TH, especially at the …
treatment, yet significant gaps in our mechanistic understanding of TH, especially at the …
High-speed, 3D volumetric displacement and strain mapping in soft materials using light field microscopy
S Buyukozturk, AK Landauer, LA Summey… - Experimental …, 2022 - Springer
Background High strain-rate deformations of soft materials occur in many applications, and
thus measurements of at-rate volumetric deformations are needed to understand physical …
thus measurements of at-rate volumetric deformations are needed to understand physical …
[PDF][PDF] Brain Multiphysics
Successful detection and prevention of brain injuries relies on the quantitative identification
of cellular injury thresholds associated with the underlying pathology. Here, by combining a …
of cellular injury thresholds associated with the underlying pathology. Here, by combining a …