Emerging biomarkers for prediction and early diagnosis of necrotizing enterocolitis in the era of metabolomics and proteomics

E Agakidou, C Agakidis, H Gika, K Sarafidis - Frontiers in Pediatrics, 2020 - frontiersin.org
Necrotizing Enterocolitis (NEC) is a catastrophic disease affecting predominantly premature
infants and is characterized by high mortality and serious long-term consequences …

Modes of action and diagnostic value of miRNAs in sepsis

N Antonakos, C Gilbert, C Theroude… - Frontiers in …, 2022 - frontiersin.org
Sepsis is a clinical syndrome defined as a dysregulated host response to infection resulting
in life-threatening organ dysfunction. Sepsis is a major public health concern associated …

MicroRNA as an early biomarker of neonatal sepsis

M Jouza, J Bohosova, A Stanikova, J Pecl… - Frontiers in …, 2022 - frontiersin.org
Sepsis is a major cause of lethality in neonatal intensive care units. Despite significant
advances in neonatal care and growing scientific knowledge about the disease, 4 of every …

An insight into miR-1290: an oncogenic miRNA with diagnostic potential

M Guz, W Jeleniewicz, M Cybulski - International Journal of Molecular …, 2022 - mdpi.com
For more than two decades, the view of the roles of non-coding RNAs (ncRNAs) has been
radically changing. These RNA molecules that are transcribed from our genome do not have …

miR‑34a increases inflammation and oxidative stress levels in patients with necrotizing enterocolitis by downregulating SIRT1 expression

H Zhu, Y Lin, Y Liu - Molecular Medicine Reports, 2021 - spandidos-publications.com
Abstract The miR‑34a/SIRT1 signaling axis is an important signaling axis in tumors and
diseases. Notably, low SIRT1 expression in the intestinal tissues of patients with necrotizing …

[HTML][HTML] MiR-141-3p ameliorates RIPK1-mediated necroptosis of intestinal epithelial cells in necrotizing enterocolitis

X Li, Y Wang, Y Wang, X He - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
Aim: To explore the effects of miR-141-3p on intestinal epithelial cells in necrotizing
enterocolitis and the underlying mechanism. Results: The expression of miR-141-3p was …

[HTML][HTML] Clinical and immunological aspects of microRNAs in neonatal sepsis

A Fatmi, N Chabni, M Cernada, M Vento… - Biomedicine & …, 2022 - Elsevier
Neonatal sepsis constitutes a highly relevant public health challenge and is the most
common cause of infant morbidity and mortality worldwide. Recent studies have …

Multimodal AI system for the rapid diagnosis and surgical prediction of necrotizing enterocolitis

W Gao, Y Pei, H Liang, J Lv, J Chen, W Zhong - Ieee Access, 2021 - ieeexplore.ieee.org
The rapid diagnosis and surgical prediction of necrotizing enterocolitis (NEC) remain a
challenge because its complex pathogenesis has not been completely elucidated, and no …

Biomarkers of necrotizing enterocolitis: the search continues

A Gunasekaran, C Devette, S Levin… - Clinics in …, 2022 - perinatology.theclinics.com
Necrotizing enterocolitis (NEC) is the most devastating gastrointestinal (GI) pathology in
preterm infants. 1, 2 NEC results in significant morbidity, and mortality rates range up to 50 …

The role and mechanisms of miRNA in neonatal necrotizing enterocolitis

L Cai, D Lai, J Gao, H Wu, B Shi, H Ji, J Tou - Frontiers in Pediatrics, 2022 - frontiersin.org
Neonatal necrotizing enterocolitis (NEC), the most significant causes of neonatal mortality, is
a disease of acute intestinal inflammation. At present, it is not clear exactly how the disease …