Pancreatic ductal adenocarcinoma (PDAC) has a rising incidence and is one of the most
lethal human malignancies. Much is known regarding the biology and pathophysiology of …

Radiation therapy (RT) continues to play an important role in the treatment of cancer.
Adaptive RT (ART) is a novel method through which RT treatments are evolving. With the …

Purpose Radiation therapy dose escalation using stereotactic body radiation therapy may
significantly improve both local control (LC) and overall survival (OS) for patients with …

Purpose Magnetic resonance (MR) image guidance may facilitate safe ultrahypofractionated
radiation dose escalation for inoperable pancreatic ductal adenocarcinoma. We conducted …

Background Hybrid magnetic resonance (MR)-Linac systems have recently been introduced
into clinical practice. The systems allow online adaption of the treatment plan with the aim of …

BACKGROUND We previously demonstrated the safety of stereotactic body radiotherapy
followed by pembrolizumab (SBRT+ P) in patients with advanced solid tumors. This phase I …

Abstract Background and Purpose Stereotactic body radiation therapy delivered using MR-
guided radiotherapy (MRgRT) and automatic breathold gating has shown to improve overall …

Background Radiation therapy (RT) dose for inoperable pancreatic ductal adenocarcinoma
(PDAC) has historically been non-ablative to avoid injuring gastrointestinal (GI) organs at …

Background and purpose We conducted a prospective, in silico imaging clinical trial to
evaluate the feasibility and potential dosimetric benefits of computed tomography-guided …

Radiation therapy is a major component of cancer treatment pathways worldwide. The main
aim of this treatment is to achieve tumor control through the delivery of ionizing radiation …