Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …

Interleukin-6 is a pleiotropic cytokine regulating different tissues and organs in diverse and
sometimes discrepant ways. The dual and sometime hermetic nature of IL-6 action has been …

Importance An association between sleep duration and the trajectory of cognitive decline
has not been conclusively demonstrated. Objective To investigate the association between …

Highlights•Aβ 1− 42-induced NLRP3 inflammasome activation in BV-2 microglia is mediated
through TLR4.•TLR4/NLRP3 signaling plays a critical role in Aβ 1− 42-induced …

Aging is associated with cognitive decline and accumulation of senescent cells in various
tissues and organs. Senolytic agents such as dasatinib and quercetin (D+ Q) in combination …

Over two-thirds of individuals aged 65 and older are obese or overweight in the United
States. Epidemiological data show an association between the degree of adiposity and …

The intestinal barrier, composed of the luminal microbiota, the mucus layer, and the physical
barrier consisting of epithelial cells and immune cells, the latter residing underneath and …

Caper (Capparis spinosa L.) is a perennial shrub of the family Capparaceae, endemic to
circum-Mediterranean countries. Caper carries a renowned nutritional value, especially in …

Alzheimer's disease (AD) is the most common form of dementia, characterized by
progressive degeneration and loss of neurons in specific regions of the central nervous …

Compelling evidence from animal and human research suggest a strong link between
inflammation and posttraumatic stress disorder (PTSD). Furthermore, recent findings support …