Integrins are vital surface adhesion receptors that mediate interactions between the
extracellular matrix (ECM) and cells and are essential for cell migration and the …

Over a century of scientific inquiry since the discovery of v-SRC but still no final judgement
on SRC function. However, a significant body of work has defined Src family kinases as key …

PURPOSE To provide recommendations for the management of patients with metastatic
clear cell renal cell carcinoma (ccRCC). METHODS An Expert Panel conducted a systematic …

Compared with traditional therapies, targeted therapy has merits in selectivity, efficacy, and
tolerability. Small molecule inhibitors are one of the primary targeted therapies for cancer …

Src is the prototypal member of Src Family tyrosine Kinases (SFKs), a large non-receptor
kinase class that controls multiple signaling pathways in animal cells. SFKs activation is …

Kidney cancer represents about 5% of all new cancer diagnoses. The most common form of
kidney cancer arises from renal epithelium, named renal cell carcinoma (RCC). This entity …

Background Cancer metastases are the main cause of lethality. The five-year survival rate
for patients diagnosed with advanced stage oral cancer is 30%. Hence, the identification of …

Background Several comparative randomised controlled trials (RCTs) have been performed
including combinations of tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors …

Pain is a major symptom of bone metastases from advanced cancer and represents a
clinical challenge to treat effectively. Basic neurobiology in preclinical animal models …

Liver metastasis is a common cause of death in colorectal cancer (CRC) patients, but
epigenetic remodeling and metabolic reprogramming for CRC liver metastasis remain …