Adaptive immune responses play critical roles in viral clearance and protection against re‐
infection, and SARS‐CoV‐2 is no exception. What is exceptional is the rapid …

The extreme diversity of the human immune system, forged and maintained throughout
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …

Understanding how human genetics influence infectious disease susceptibility offers the
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …

The cardiovascular system is subject to hyperlipidaemic, inflammatory, and pro-oxidant
stressors. Over time, these factors drive prevalent chronic diseases, of which atherosclerosis …

Antibody dependent cellular cytotoxicity (ADCC) is an Fc-dependent effector function of IgG
important for anti-viral immunity and anti-tumor therapies. NK-cell mediated ADCC is mainly …

IgG antibodies are secreted from B cells and bind to a variety of pathogens to control
infections as well as contribute to inflammatory diseases. Many of the functions of IgGs are …

Activation of the humoral immune system is initiated when antibodies recognize an antigen
and trigger effector functions through the interaction with Fc engaging molecules. The most …

Background Humoral immune responses to infectious agents or vaccination vary
substantially among individuals, and many of the factors responsible for this variability …

Background The ability to quantify an immune response after vaccination against severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential. This study assessed …

The recombination between immunoglobulin (IG) gene segments determines an individual's
naïve antibody repertoire and, consequently,(auto) antigen recognition. Emerging evidence …