Polyamines are low molecular weight, aliphatic polycations found in the cells of all living
organisms. Due to their positive charges, polyamines bind to macromolecules such as DNA …

Selection of the translational initiation site in most eukaryotic mRNAs appears to occur via a
scanning mechanism which predicts that proximity to the 5′ end plays a dominant role in …

Background Polyamines are small polycationic molecules found ubiquitously in all
organisms and function in a wide variety of biological processes. In the past decade …

Error s in protein synthesis disrupt cellular fitness, cause disease phenotypes and shape
gene and genome evolution. Experimental and theoretical results on this topic have …

Polyamines are aliphatic cations with multiple functions and are essential for life. Cellular
polyamine levels are regulated by multiple pathways such as synthesis from amino acid …

RNA medicines represent a paradigm shift in treatment and prevention of critical diseases of
global significance, eg, infectious diseases. The highly successful messenger RNA (mRNA) …

Genetic decoding is not 'frozen'as was earlier thought, but dynamic. One facet of this is
frameshifting that often results in synthesis of a C-terminal region encoded by a new frame …

Ornithine decarboxylase (ODC) initiates the polyamine biosynthetic pathway. The amount of
ODC is altered in response to many growth factors, oncogenes, and tumor promoters and to …

The polyamines spermidine and spermine along with the diamine putrescine are involved in
many cellular processes, including chromatin condensation, maintenance of DNA structure …

This chapter provides an overview of the polyamine field and introduces the 32 other
chapters that make up this volume. These chapters provide a wide range of methods …